谷氨酰胺联合EENs对重症急性胰腺炎患者炎性因子及营养代谢的影响

Effects of Glutamine Combined with EENs on Inflammatory Factors and Nutrient Metabolism in Patients with Severe Acute Pancreatitis

目的探讨谷氨酰胺联合EENs对重症急性胰腺炎患者炎性因子及营养代谢的影响。方法80例重症急性胰腺炎患者随机分为两组各40例。两组入院后均予以基础治疗,此外,对照组采用EENs治疗,观察组采用谷氨酰胺联合EENs治疗。比较两组的炎性因子、营养代谢指标以及并发症。结果治疗后,两组的炎性因子IL-6、IL-8、TNF-α水平均较治疗前显著下降,且观察组各指标均显著低于对照组(P<0.05)。治疗后,两组的PA水平均较治疗前显著升高,TRF水平均较治疗前显著降低(P<0.05);观察组的PA、TRF水平均显著优于对照组(P<0.05)。观察组的并发症总发生率显著低于对照组(P<0.05)。结论谷氨酰胺联合EENs治疗重症胰腺炎患者可降低炎性因子水平,改善营养代谢,降低并发症发生率。

Objective To explore the effects of glutamine combined with EENs on inflammatory factors and nutrient metabolism in patients with severe acute pancreatitis.Methods 80 patients with severe acute pancreatitis were randomly and equally divided into two groups.After admission,both groups were given basic treatment;in addition,the control group was treated with EENs,while the observation group was treated with glutamine combined with EENs.The inflammatory factors,nutrient metabolism and complications were compared between two groups.Results After treatment,the levels of inflammatory cytokines including IL-6,IL-8 and TNF-αof both groups were significantly lower than those before treatment,and the levels of inflammatory cytokines of the observation group were significantly lower than those of the control group(P<0.05).After treatment,the PA levels of both groups were significantly higher than those before treatment,and the TRF levels were significantly lower than those before treatment(P<0.05);The levels of PA and TRF of the observation group were significantly better than those of the control group(P<0.05).The total incidence of complications of the observation group was significantly lower than that of the control group(P<0.05).Conclusions Glutamine combined with EENs in the treatment of patients with severe acute pancreatitis can reduce the levels of inflammatory factors,improve nutrient metabolism and reduce the incidence of complications.