小剂量西那卡塞联合骨化三醇治疗维持性血液透析继发性甲状旁腺亢进患者的临床疗效观察

Observation on the Clinical Efficacy of Small-Dose Cinacalcet Combined with Calcitriol in the Treatment of Patients with Secondary Hyperparathyroidism of Maintenance Hemodialysis

目的探讨小剂量西那卡塞联合骨化三醇治疗维持性血液透析继发性甲状旁腺亢进患者的临床疗效。方法60例维持性血液透析继发性甲状旁腺功能亢进患者随机分为两组各30例。对照组采用骨化三醇治疗,观察组采用小剂量西那卡塞联合骨化三醇治疗。比较两组的临床疗效,以及治疗前后的血钙(Sca)、血磷(Sp)、血清碱性磷酸酶(ALP)、免疫反应性甲状旁腺素(iPTH)水平。结果观察组的治疗总有效率为93.33%,显著高于对照组的73.33%(P<0.05)。治疗后,观察组的Sca、Sp、iPTH水平均显著低于治疗前和对照组,ALP水平显著高于治疗前和对照组(P<0.05)。结论小剂量西那卡塞联合骨化三醇治疗维持性血液透析继发性甲状旁腺亢进的疗效确切,可促进患者临床指标的改善。

Objective To observe the clinical efficacy of small-dose cinacalcet combined with calcitriol in the treatment of patients with secondary hyperparathyroidism of maintenance hemodialysis.Methods 60 patients with secondary hyperparathyroidism of maintenance hemodialysis were randomly divided into two groups,with 30 cases in each group.The control group was treated with calcitriol,and the observation group was treated with small-dose cinacalcet combined with calcitriol.The clinical efficacy,and the levels of serum calcium(Sca),serum phosphorus(Sp),serum alkaline phosphatase(ALP)and immunoreactive parathyroid hormone(iPTH)before and after treatment were compared between two groups.Results The total effective rate of treatment of observation group was 93.33%,significantly higher than 73.33%of control group(P<0.05).After treatment,the levels of Sca,Sp and iPTH of observation group were significantly lower than those before treatment and those of control group,and the level of ALP was significantly higher than that before treatment and that of control group(P<0.05).Conclusions Small-dose cinacalcet combined with calcitriol in the treatment of secondary hyperparathyroidism of maintenance hemodialysis has exact efficacy,and can promote the improvement of clinical indicators of patients.