高血压合并高同型半胱氨酸血症患者叶酸代谢相关基因多态性研究进展

Advances in research on gene polymorphisms of folate metabolism in patients with hypertension and hyperhomocysteinemia

近年来的研究结果显示,同型半胱氨酸水平与心脑血管疾病、肾脏疾病、肝脏疾病以及糖尿病等多种疾病有关。在我国,高血压患者合并同型半胱氨酸水平升高的现象普遍存在,而高血压和高同型半胱氨酸血症协同作用,因此研究高血压合并高同型半胱氨酸血症具有重要意义。叶酸代谢相关基因多态性与血浆同型半胱氨酸水平密切相关,文章对高血压合并高同型半胱氨酸血症患者叶酸代谢相关基因多态性的研究进展进行了概述,为高血压合并高同型半胱氨酸血症患者与相关基因多态性的关系研究提供新的证据。

Recent studies have shown that the levels of homocysteine are associated with various diseases such as cardiovascular and cerebrovascular diseases,kidney diseases,liver diseases,diabetes and so on.In China,hypertensive patients with elevated levels of homocysteine are common,while hypertension and hyperhomocysteinemia work synergistically,so it is important to study hypertension with hyperhomocysteinemia.Polymorphisms in folate metabolism-related genes are closely related to plasma homocysteine levels.This article summarized the research progress of folate metabolism related gene polymorphisms in patients with hypertension and hyperhomocysteinemia,and provide new evidence for the relationship between patients with hypertension and hyperhomocysteinemia and some related gene polymorphism.