尼可地尔治疗急性冠脉综合征的疗效及对冠脉微循环血清炎症指标的影响

Curative Efficacy of Nicorandil on Acute Coronary Syndrome and Its Effects on Coronary Microcirculation and Serum Inflammation Indexes

目的:分析ACS(急性冠脉综合征)患者CABG(冠状动脉搭桥术)术后给予尼可地尔对TIMI分级、冠脉微循环、血清炎症指标的影响。方法:研究本院2018年1月至2019年12月收治的86例ACS患者,随机数字表法分组(每组43例),基础治疗组在CABG术后给予临床常规治疗,尼可地尔组在基础治疗组基础上给予尼可地尔治疗,对比两组TIMI血流分级、冠脉微循环、血清炎症指标、不良反应发生情况。结果:治疗4周后尼可地尔组TIMI分级明显优于基础治疗组,尼可地尔组治疗4周后IMR、IL-6、hs-CRP、TNF-a指标均明显低于基础治疗组,P<0.05(差异均具有统计学意义)。尼可地尔组不良反应发生率(9.30%)与基础治疗组(6.98%)比较,P>0.05(差异无统计学意义)。结论:尼可地尔应用于ACS患者CABG术后,可有效改善冠状动脉再灌注情况,减轻炎症反应,且不良反应较少,值得借鉴。

Objective:To analyze the effects of nicorandil on TIMI classification,coronary microcirculation,and serum inflammation indexes after CABG(coronary artery bypass surgery)in patients with ACS(acute coronary syndrome).Methods:86 patients with ACS admitted to our hospital from January 2018 to December 2019 were grouped with random number table(43 cases in each group).The basic treatment group was given routine clinical treatment after CABG surgery,and the nicorandil group was treated with nicorandil more than the treatment group,and the TIMI blood flow classification,coronary microcirculation,serum inflammation indicators,and adverse reactions were compared between the two groups.Results:After 4 weeks of treatment,the TIMI grade of the nicorandil group was significantly better than that of the basic treatment group.The IMR,IL-6,hs-CRP,and TNF-a indexes of the nicorandil group were significantly lower than those of the basic treatment group.The differences were statistically significant(P<0.05).The incidence of adverse reactions(9.30%)in the nicorandil group was compared with the basic treatment group(6.98%),and the difference was not statistically significant(P>0.05).Conclusion:Nicorandil applied to patients with ACS after CABG surgery can effectively improve coronary reperfusion,reduce inflammation,and has fewer adverse reactions,which is worthy of reference.