阻塞性睡眠呼吸暂停综合征与视网膜分支静脉阻塞的关系

Relationship between obstructive sleep apnea syndrome and branch retinal vein occlusion

目的:探讨阻塞性睡眠呼吸暂停综合征(OSAS)与视网膜分支静脉阻塞(BRVO)的相关性。方法:本研究共纳入70例BRVO患者及70例健康体检者作为对照(与BRVO患者的年龄、性别相匹配)。利用Berlin问卷对BRVO患者及对照组的OSAS患病风险进行评估,借助多导睡眠呼吸监测仪对BRVO患者及对照组的呼吸暂停低通气指数(AHI)、最小氧饱和度(MOS)等指标进行监测。根据AHI对OSAS进行诊断,对BRVO患者及对照组的OSAS发生率、平均AHI、平均MOS等指标进行比较。结果:BRVO患者中伴发OSAS者为49例(70%),平均AHI为19.74±7.59、MOS为(82.45±9.17)%;对照组OSAS患者为23例(33%),平均AHI为13.69±6.35、MOS为(88.44±8.72)%。BRVO患者及对照组OSAS的发病率、平均AHI及MOS均有差异(χ^2=19.331,t=5.115、3.954,均P<0.01)。OSAS与BRVO呈正相关(rs=0.319,P=0.033)。39例急性BRVO患者的平均AHI为16.905±6.31、MOS为(85.14±8.22)%;31例慢性BRVO患者的平均AHI为17.84±5.47、MOS为(83.81±7.87)%,急性BRVO患者与慢性BRVO患者的平均AHI和MOS均无差异(t=0.653、0.685,P=0.516、0.496)。结论:OSAS可能是BRVO的重要危险因素,其对于BRVO病情的持续也可能起着关键作用。

AIM:To evaluate the relationship between obstructive sleep apnea syndrome(OSAS)and branch retinal vein occlusion(BRVO).METHODS:Seventy consecutive patients with BRVO and 70 age-and sex-matched controls were evaluated retrospectively.All participants underwent Berlin questionnaire and full-night respiratory polysomnography(PSG)for estimating risk of OSAS and monitoring apnea-hypopnea index(AHI),minimal oxygen saturation(MOS).RESULTS:Of the 70 BRVO patients,49(70%)had OSAS,average AHI was(19.74±7.59),MOS was(82.45±9.17)%.For controls,only 23(33%)of 70 subjects had OSAS,average AHI was(13.69±6.35),average MOS was(88.44±8.72)%in controls.Incidence of OSAS,AHI and MOS between BRVO patients and controls were different significantly(χ^2=19.331,t=5.115,3.954,all P<0.01).There was a positive correlation between OSAS and BRVO(rs=0.319,P=0.033).Of the 39 patients with acute BRVO,average AHI was(16.905±6.31),average MOS was(85.14±8.22)%.For the 31 patients with chronic BRVO,average AHI was(17.84±5.47),average MOS was(83.81±7.87)%.There were no significantly differences between acute BRVO patients and chronic BRVO patients in average AHI or MOS(t=0.653,0.685,P=0.516,0.496).CONCLUSION:OSAS could be a trigger in the pathogenesis of BRVO or an important risk factor of CRVO development.