HPV感染对阴道微生态炎症反应的影响

The effect of HPV infection on vaginal microecology and inflammatory responses

目的探究HPV感染与阴道微生态、炎症反应的关系。方法选取2017年11月至2018年11月在我院治疗的70例HPV感染患者(研究组),随机选取同一时期来我院进行体检的健康者70例(对照组)。治疗前后分别对研究组和对照组研究对象进行HPV检测、阴道分泌物检查以及炎症反应检查,观察并记录两组研究对象的情况。结果治疗前研究组患者HPV感染情况[高危型HPV感染31例(44.3%),低危型HPV感染为39例(55.7%)]明显高于对照组[高危型HPV感染2例(2.8%),低危型HPV感染5例(7.1%)](t=38.3140、33.3450,均P<0.05);研究组患者阴道微生态(乳杆菌为3000±50、厌氧菌为1050±100、需氧菌为800±65)明显低于对照组(乳杆菌为5114±222、厌氧菌为2334±100、需氧菌为1500±100)(t=15.3951、14.5211、16.1260,均P<0.05);研究组阴道炎症发病情况[阴道毛滴虫阴道炎29例(41.43%)、念珠菌阴道炎为22例(31.43%)、细菌性阴道炎19例(27.14%)]明显多于对照组[阴道毛滴虫阴道炎11例(15.71%)、念珠菌阴道炎9例(12.86%)、细菌性阴道炎8例(11.43%)](χ^2=11.3400、7.0020、5.5520,均P<0.05)。结论临床上HPV感染很常见,患者多伴发阴道炎症,HPV感染患者阴道正常菌群变少,阴道微生态环境紊乱。

Objective To explore the relationship between HPV infection and vaginal microecology and inflammatory responses.Methods Seventy patients with HPV infection who were treated in our hospital from November 2017 to November 2018 were selected as the Observation group.Seventy patients who underwent physical examination in our hospital during the same period were randomly selected as the control group.Before and after treatment,detections of HPV,vaginal secretion and inflammatory reactions were performed in both groups.The basic conditions of patients in the two groups was observed and compared.Results The rate of HPV infection in the observation group(31 cases of high-risk HPV infection,44.3%;39 cases of low-risk HPV infection,55.7%)was significantly higher than that in the control group(2 cases of high-risk HPV infection,2.8%;5 cases of low-risk HPV infection,7.1%)(t=38.3140,33.3450,all P<0.05).The vaginal micro-ecology in the observation group(3000±50 for Lactobacilli,1050±100 for anaerobic bacteria,800±65 for aerobic bacteria)was significantly lower than in the control group(5114±222 for Lactobacillus,2334±100 for anaerobic bacteria,1500±100 for aerobic bacteria)(t=15.3951,14.5211,16.1260,all P<0.05).The incidence of vaginal inflammation in the observation group[29(41.43%)cases of Trichomonas vaginalis,22(31.43%)cases of candida vaginitis,19(27.14%)cases of bacterial vaginitis]were significantly higher than in the control group[11(15.71%)cases of Trichomonas vaginalis,9(12.86%)cases of Candida vaginitis,8(11.43%)cases of bacterial vaginitis](χ^2=11.3400,7.0020,5.5520,all P<0.05).Conclusion Clinically,HPV infection is very common with concurrent vaginal inflammation;the patients have decreased normal vaginal flora and imbalanced vaginal micro-ecological environment.