Fe3O4磁性纳米颗粒的RAFT试剂化研究

Functionalization of Fe3O4 magnetic nanoparticles using RAFT reagent

通过反相微乳液法制备四氧化三铁纳米颗粒(Fe3O4 NPs),并用硅烷偶联剂KH570对其改性,以期在Fe3O4 NPs表面引入C==C双键,再利用引入的C==C双键与三硫代十二烷酸-2-氰基异丙酯(RAFT试剂)进行反应,得到RAFT试剂化的Fe3O4 NPs(Fe3O4-g-KH570-RAFT NPs),并对不同阶段的Fe3O4 NPs产物的结构与形貌等进行表征.研究中以RAFT试剂接枝率(GrRAFT)为指标,考察了反应时间等工艺条件对GrRAFT的影响.结果表明:制备的Fe3O4-g-KH570-RAFT NPs的平均粒径为10.4 nm,当反应时间为14 h,反应温度为65℃,nKH570/nRAFT为1/2时,接枝率GrRAFT最高达到79.34%.

Ferric oxide nanoparticles(Fe3O4 NPs)were prepared in this study by reverse microemulsion method,and modified by silane coupling agent KH570 so as to introduce cellulc double bond on the surface of Fe3O4 NPs,and then react with 2-cyanopropan-2-propanyl dodecyl trithiocarbonate to obtain RAFT reacted Fe3O4 NPs(Fe3O4-g-KH570-RAFT NPs).The structure and morphology of Fe3O4 NPs products at different stages were also characterized.Effects of reaction time and other process conditions on GrRAFT were investigated quantitatively in the study by taking the grafting rate of RAFT reagent(GrRAFT)as an index.The results show that the average particle size of the prepared Fe3O4-g-KH570-RAFT NPs is about 10.4 nm.When the reaction time takes 14 h,the reaction temperature is 65℃,and nKH570/nRAFT becomes 1/2,the highest grafting rate GrRAFT may reach up to 79.34%.