硫酸镁联合硝苯地平治疗妊娠期高血压疾病的临床效果观察

Clinical Effect of Magnesium Sulfate Combined with Nifedipine in Treatment of Hypertension during Pregnancy

目的观察硫酸镁联合硝苯地平治疗妊娠期高血压疾病的临床效果。方法选取北京市仁和医院2017年1月至2019年6月收治的72例妊娠期高血压疾病患者进行研究。按就诊编号分为对照组(36例)与试验组(36例),对照组使用硫酸镁治疗,试验组使用硫酸镁+硝苯地平片治疗。比较两组患者治疗的疗效和妊娠结果。结果治疗后,比较两组患者的收缩压、舒张压,试验组低于对照组,差异有统计学意义(P<0.05);两组患者血粘度、红细胞压积指标比较差异无统计学意义(P>0.05),试验组24 h尿蛋白低于对照组,差异有统计学意义(P<0.05)。试验组治疗总有效率高于对照组,差异有统计学意义(P<0.05);试验组不良妊娠发生率低于对照组,差异有统计学意义(P<0.05)。结论硫酸镁联合硝苯地平治疗妊娠期高血压疾病疗效确切,能进一步提高降压效果、改善妊娠结局。

Objective To observe the clinical effect of magnesium sulfate combined with nifedipine in the treatment of hypertension during pregnancy.Methods Seventy-two patients with gestational hypertension treated in Beijing Renhe Hospital from January 2017 to June 2019 were selected and divided into control group and experimental group according to the number of visits,36 cases each.The control group was treated with magnesium sulfate;the experimental group was treated with magnesium sulfate+nifedipine tablets.The efficacy and pregnancy outcome between the two groups were compared.Results After treatment,the systolic and diastolic blood pressures of the experimental group were lower than those of the control group,the difference was statistically significant(P<0.05).There was no significant difference in blood viscosity and hematocrit between the two groups(P>0.05).The 24-hour urinary protein in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05).The total effective rate in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse pregnancy in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Magnesium sulfate combined with nifedipine has a definite effect on the treatment of hypertension during pregnancy,which can further improve the effect of reducing blood pressure and improve the outcome of pregnancy.