摘要
目的:探讨白细胞表达趋势在监测癌前病损和OSCC早期诊断中的价值。方法:对OSCC患者(52例)、口腔扁平苔藓(OLP)患者(61例)及正常口腔黏膜(NOM)者(55例)血常规中白细胞各项参数进行回顾性分析。结果:在OSCC组中:MONO、MONO-R、EOS、EOS-R指标均高于OLP和(或)NOM组;BASO、BASO-R、LYM、LYM-R指标低于NOM和(或)OLP组(P<0.05)。结论:白细胞亚型的表达趋势可能作为监测OLP即癌前病损恶变、早期诊断OSCC的依据。
Objective:To explore the value of leukocyte expression trend in monitoring precancerous lesion and early diagnosis of oral squamous cell carcinoma(OSCC).Methods:The leukocyte parameters in patients with OSCC cancer(52 cases),oral lichen planus(OLP)patients(61 cases)and normal oral mucous membrane(NOM)(55 cases)were measured and analyzed retrospectively.Results:The indexes of MONO,MONO-R,EOS and EOS-R in OSCC group were higher than those of OLP and(or)NOM group,while the indexes of BASO,BASO-R,LYM and LYM-R in OSCC group were lower than those of NOM and(or)OLP group(P<0.05).Conclusion:The expression trend leukocyte subtypes may be used as an effective basis for monitoring precancerous lesion and malignancy,and early diagnosis of OSCC.
作者
李腾艳
聂敏海
陈潇
刘旭倩
LI Tengyan;NIE Minhai;CHEN Xiao;LIU Xuqian(Department of Periodontics&Oral Mucosal Diseases,The Affiliated Stomatology Hospital of Southwest Medical University,Oral&Maxillofacial Reconstruction and Regeneration Laboratory,Southwest Medical University,646000 Luzhou,China;Department of Orthodontic,Mianyang Stomatological Hospital)
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2020年第5期753-757,共5页
Journal of Practical Stomatology
基金
四川省科技计划项目(编号:2018JY0401)
四川省科学技术厅科技计划项目(编号:2020YJ0387)
四川省泸州市人民政府-西南医科大学科技战略合作重点项目(编号:2019LZXNYDZ10)。
关键词
白细胞
口腔鳞状细胞癌(OSCC)
癌前病损
炎症
超敏反应
Leukocytes
Oral squamous cell carcinoma(OSCC)
Precancerous lesion
Inflammation
Hypersensitivity
