胼胝体分离综合征神经心理学特征的诊疗流程及应用

Diagnosis and treatment process of neuropsychological characteristics of callosal disconnection syndrome and its application

目的:本研究拟通过标准的诊断流程,分析胼胝体分离综合征(CDS)的神经心理学特征,为临床诊疗提供客观依据。方法:回顾性分析8例CDS患者的病因、神经心理学表现及影像学特点。结果:影像学提示患者均为缺血性卒中,病灶均累及胼胝体,其中膝部6例、体部8例、压部4例;患者均伴有认知障碍,MoCA评分为(19.00±4.11),均<26分;神经心理学表现复杂多样,评估显示偏瘫(8/8例)、异己手综合征(8/8例)、失语症(3/8例)、触觉失认(4/8例)、失用症(5/8例)、失读症(4/8例)、失写症(4/8例)、偏侧忽略(3/8例)、精神障碍(4/8例)。结论:CDS临床表现和神经心理学特征复杂多变,标准的评估流程有助于明确诊断,为临床诊疗提供可靠依据。

Objective:To summarize the neuropsychological characteristics of callosal disconnection syndrome(CDS)with standard diagnostic process,and to provide the basis for clinical diagnosis and treatment.Method:A retrospective analysis was made of the etiologic factors,clinical manifestations,neuropsychological characteristics and prognosis of 8 CDS patients.Result:Imaging findings suggested that all patients had ischemic stroke,and the lesions involved corpus callosum all,of which 6 were at the genu,8 were at the body,and 4 were at the splenium,the MoCA score was(19.00±4.11),all<26 points.The neuropsychological manifestations were complex and diverse,including limb hemiplegia(8/8),Alien hand syndrome(8/8),aphasia(3/8),tactile agnosia(4/8),apraxia(5/8),dyslexia(4/8),agraphia(4/8),hemispatial neglect(3/8),and mental disorders(4/8).Conclusion:The clinical manifestations and neuropsychological manifestations of CDS are diverse,and the standard diagnostic process is helpful to make diagnosis and provide a reliable basis for clinical treatment.