胃肠助显剂对胰腺经腹超声可视化质量影响的队列研究

A cohort study on the effects of gastrointestinal adjuvant on pancreatic transabdominal ultrasound visual quality

目的探讨胃肠助显剂对经腹超声胰腺可视化质量的影响。方法招募220名健康志愿者随机分为2组,每组110名,2组性别比、年龄、体重指数(BMI)差异无统计学意义(P>0.05)。第一组(助显剂组)分别于空腹及服用助显剂后卧位进行经腹胰腺超声检查,对胰头、胰体、胰尾的可视化质量进行评分(1分=不可见,2分=成像质量差,3分=成像质量尚可,4分=成像质量好,5分=成像质量优)。对空腹和服用助显剂后的胰腺可视化质量进行比较,计算两种状态下可视化质量<3分的例数所占比例。第二组(温开水组)分别于空腹及服用温开水后对胰腺进行前述相同方法的超声检查和评分并对可视化质量进行比较。对服用助显剂后和服用温开水后胰腺的可视化质量进行比较。对220例空腹状态时胰头、胰体、胰尾之间的可视化质量进行比较,对服用助显剂后胰头、胰体、胰尾之间的可视化质量进行比较,对服用温开水后胰头、胰体、胰尾之间的可视化质量进行比较。结果空腹状态与服用助显剂后胰腺超声可视化质量差异有统计学意义(P<0.001)。第一组中空腹状态可视化质量<3分的比例分别为胰头39%、胰体20%、胰尾60%,服用助显剂后可视化质量<3分的比例分别为胰头8%、胰体2%、胰尾8%。空腹状态与服用温开水后胰腺经腹超声可视化质量差异有统计学意义(P<0.001)。第二组中空腹状态可视化质量<3分的比例分别为胰头41%,胰体16%,胰尾65%,服用温开水后可视化质量<3分的比例分别为胰头15%,胰体4%,胰尾40%。服用助显剂后与服用温开水后胰腺可视化质量比较差异有统计学意义(P<0.001)。结论胃肠助显剂可以明显改善胰腺经腹超声可视化质量、应用方便、无明显不良反应。

Objective To investigate the effects of gastrointestinal adjuvant on pancreatic transabdominal ultrasound visual quality.Methods A total of 220 healthy volunteers enrolled in the study,who were randomly divided into two groups,with 110 subjects in each group.There were no significant differences in gender,age and body mass index(BMI)between the two groups.The subjects in group 1 underwent transabdominal ultrasound of the pancreas in a supine position in fasting status and taking adjuvant state.The visualization quality of pancreas was graded on a scale of 1 to 5(1=nonvisualization,2=poor,3=fair,4=good,and 5=excellent visualization).The visual quality of pancreas in fasting status was compared with that in the state of taking adjuvant,and the proportion of cases with visual quality score<3 in the two states was calculated.Moreover the visual quality of pancreas in different conditions was compared,and the visual quality was compared among the head,body and tail of the pancreas.Results There was significant difference in the pancreatic transabdominal ultrasound visual quality between fasting status and after taking adjuvant(P<0.01).The proportion of visual quality<3 in fasting state in group 1 was 39%in pancreatic head,20%in pancreatic body and 60%in pancreatic tail,and the proportion of visual quality<3 after taking adjuvant was 8%in pancreatic head,2%in pancreatic body and 8%in pancreatic tail.There was significant difference in the pancreatic transabdominal ultrasound visual quality between fasting status and after taking warm water(P<0.01).And the proportion of visual quality<3 in fasting state in group 2 was 41%in pancreatic head,16%in pancreatic body and 65%in pancreatic tail,the proportion of visual quality<3 after drinking warm water was 15%in pancreatic head,4%in pancreatic body and 40%in pancreatic tail.There was significant difference in the pancreatic transabdominal ultrasound visual quality between drinking warm water and taking adjuvant(P<0.01).Conclusion The gastrointestinal adjuvant can significantly improve the quality of transabdominal ultrasound visualization of the pancreas,it is easy to be uses,without obvious side effects.