无痛人工流产术中不同剂量喷他佐辛或舒芬太尼联合丙泊酚麻醉效果比较

Analysis of clinical efficacy of different doses of pentazocine or sufentanil with propofol in painless induced abortion

目的:探讨不同剂量喷他佐辛或舒芬太尼联合丙泊酚对行无痛人工流产应用效果。方法:选取本院要求行无痛人工流产术者120例,根据麻醉方式的不同分为3组各40例,喷他佐辛(0.2 mg/kg)联合丙泊酚(低剂量组),喷他佐辛(0.3mg/kg)联合丙泊酚(高剂量组),舒芬太尼联合丙泊酚(舒芬太尼组),比较3组麻醉效果。结果:低剂量组、高剂量组、舒芬太尼组麻醉总有效率(95.0、87.5%、92.5%)无差异(P>0.05);高剂量组苏醒及离室时间均长于另外两组(P<0.05);3组间术中丙泊酚用量、阿托品用量、多巴胺用量无差异,术后24h镇痛比较无差异(P均>0.05);术后麻醉相关不良反应低剂量组发生率(15.0%)低于高剂量组(42.5%)和舒芬太尼组(55.0%)(P<0.05)。结论:0.2 mg/kg喷他佐辛联合丙泊酚在无痛人工流产术镇痛镇静效果与舒芬太尼联合丙泊酚相当,但术后恢复更快,可更好地降低麻醉相关不良反应发生,安全性更佳。

Objective:To investigate the clinical efficacy of different doses of pentazocine or sufentanil with propofol in painless induced abortion.Methods:120 women wanted painless induced abortion were selected as research subjects and were divided into 3 groups(40 cases in each group).The women in group A were given 0.2mg/kg pentazocine with propofol therapy,the women in group B were given 0.3mg/kg pentazocine with propofol therapy,and the women in group C were given sufentanil with propofol therapy.The anesthetic effect of women was compared among the three groups.Results:The total anesthesia effective rate of women in group A,group B,and group C were 95.0,87.5%,and 92.5%,respectively,which had no significant different(P>0.05).The time of wake and stay in hospital time of women in group B were significant longer than those of women in the other two groups(P<0.05).There were no significant different in the dosages of propofol,atropine,and dopamine during abortion,and the analgesic effect 24h after abortion among the three groups(all P>0.05).The incidence of postoperative anesthesia related adverse reactions of women in group A(15.0%)was significant lower than that(42.5%)of women in group B and that(55.0%)of women in group C(P<0.05).Conclusion:0.2mg/kg pentazocine combined with propofolin used in painless induced abortion has good anesthesia effect with faster postoperative recovery,which can reduce the occurrence of anesthesia related adverse reactions,and has better safety.