外周血清α1抗胰蛋白酶联合绒毛膜促性腺激素对先兆流产妊娠结局的预测价值

The value of serumα1 antitrypsin level combined with the chorionic gonadotropin level for predicting the pregnancy outcomes of women with threatened abortion

目的:探究外周血清α1抗胰蛋白酶(α1 AT)联合孕酮(P)及绒毛膜促性腺激素(βhCG)对先兆流产妊娠结局的预测价值。方法:回顾性收集本院妇产科2017年6月—2018年12月收治的112例先兆流产患者,根据妊娠结局分为流产组(n=56)和继续妊娠组(n=56);同期正常妊娠孕妇56例为对照组。检测各组孕妇外周血清α1 AT、βhCG及P水平。采用ROC受试分析曲线评估上述检测对先兆流产妊娠结局的预测价值。结果:流产组P、βhCG及α1 AT水平均低于继续妊娠组和正常组(P<0.05),而继续妊娠组与对照组P水平无差异(P>0.05)。ROC曲线分析,α1 AT与βhCG水平对流产的预测准确性(70.3%、73.3%)优于P(46.4%)。治疗后48 h及72 h,流产组患者P、βhCG及α1 AT水平仍低于继续妊娠组(P<0.05)。结论:血清α1 AT联合βhCG检测有助于对先兆流产患者预后的评估,对临床早期预防干预具有重要指导意义。

Objective:To explore the value of the detection of peripheral serumα1 antitrypsin(α1 AT)level combined with the chorionic gonadotropin level for predicting the pregnancy outcomes of women with threatened abortion.Methods:The data of 112 women with threatened abortion were collected retrospectively from June 2017 to December 2018.According to the pregnancy outcomes,these women were divided into group A(56 women with abortion)and group B(56 women with continues pregnancy).During the same time,56 normal pregnant women were selected in group C.The levels of serumα1 AT,βhCG,and progesterone(P)of women in the three groups were detected.ROC curve analysis was used to evaluate the predictive value ofα1 AT andβhCG levels for pregnancy outcomes of women with threatened abortion.Results:The levels of P,βhCG,andα1 AT of women in group A were significant lower than those of women in group B and C(P<0.05),but which had no significant different between group B and group C(P>0.05).ROC curve analysis showed that serum P,βhCG andα1 AT levels of women in the group A had predictive value for threatened abortion.The accuracy ofα1 AT level andβhCG level for predicting abortion were 70.3%and 73.3%,which were significant higher than that(46.4%)of P level.48 h and 72 h After treatment,the levels of P,βhCG andα1 AT of women in group A were also significant lower than those of women in group B(P<0.05).Conclusion:The combined detection of serumα1 AT level andβhCG level can help to evaluate the prognosis of women with threatened abortion,which has important guiding significance for early preventing threatened abortion.