MAPK信号通路在自然流产中机制研究进展

Research progress of MAPK signal pathway in spontaneous abortion

自然流产是病理妊娠中的一种,病因和发病机理复杂,其中一部分病因已被普遍接受,然而还有50%不明原因的自然流产,其发病机制尚不清楚。近年研究发现,丝裂原活化蛋白激酶(MAPK)通路在胚胎发育、滋养层细胞入侵、蜕膜免疫微环境中发挥重要作用,病理妊娠的发生可能与MAPK通路异常有极大关系。本文对MAPK信号通路与自然流产的关系进行综述,为临床上防治自然流产提供理论参考。

Spontaneous abortion is one of the pathological pregnancies,and its etiology and pathogenesis are complicated.Some of the causes have been generally accepted.However,there are still 50%of spontaneous abortions with unknown causes,and its pathogenesis is still unclear.In recent years,researches have found that the MAPK signal pathway plays an important role in embryonic development,trophoblast cells invasion,and decidual immune microenvironment.The occurrence of pathological pregnancy may be greatly related to the abnormal MAPK signal pathway.Therefore,this article will review the relationship between MAPK signal pathway and spontaneous abortion,in order to provide theoretical evidences for the clinical prevention and treatment of spontaneous abortion.