射频消融术联合EGFR-TKIs治疗EGFR突变型肺癌的效果及Th1/Th2细胞免疫观察

Effect of radiofrequency ablation combined with EGFR-TKIs in the treatment of EGFR mutant lung cancer and observation of Th1/Th2 cell immunity

目的:研究射频消融术联合EGFR-TKIs治疗EGFR突变型肺癌的效果及Th1/Th2细胞免疫观察。方法:124例EGFR突变型肺癌患者按照随机数表法分为对照组和观察组,每组各62例。对照组患者均接受EGFR-TKIs治疗,观察组在对照组基础上实施射频消融术治疗。比较两组治疗疗效,并观察两组Th1/Th2细胞免疫水平,分析两组并发症发生情况及2年生存率。结果:观察组治疗有效率和局部控制率高于对照组(P<0.05);两组治疗后Th1型细胞因子TNF-α、IFN-γ、IL-2及Th2型细胞因子IL-4、IL-10、IL-5水平与治疗前比较,差异有统计学差异(P<0.05),且观察组改善幅度更高(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05);观察组2年总生存率明显高于对照组(P<0.05)。结论:应用射频消融术联合EGFR-TKIs可有效调节EGFR突变型肺癌患者免疫功能,提高疗效,延长生存期,且方法微创、安全,值得临床推广。

Objective:To study the effect of radiofrequency ablation combined with EGFR-TKIs in the treatment of EGFR mutant lung cancer and the observation of Th1/Th2 cell immunity.Methods:124 patients with EGFR mutant lung cancer were randomly divided into control group and observation group,62 cases in each group.The control group patients received EGFR-TKIs treatment,and the observation group received radiofrequency ablation treatment on the basis of the control group.The therapeutic effect of the two groups was compared,and the Th1/Th2 cellular immune level of the two groups was observed,and the complications and 2-year survival rate of the two groups were analyzed.Results:The treatment efficiency and local control rate of the observation group were higher than those of the control group(P<0.05).The levels of Th1 type cytokines TNF-α,IFN-γ,IL-2,Th2 type cytokines IL-4,IL-10,IL-5 levels after treatment were statistically different from those before treatment(P<0.05),and the improvement of the observation group was higher(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).The 2-year overall survival rate of the observation group was significantly higher than that in the control group(P<0.05).Conclusion:For patients with EGFR mutant lung cancer,radiofrequency ablation combined with EGFR-TKIs can effectively regulate the immune function of patients,improve the efficacy and prolong the survival period,and the method is minimally invasive,safe,and worthy of clinical promotion.