内镜黏膜下剥离术治疗早期胃癌及癌前病变的临床效果观察

Clinical efficacy of endoscopic submucosal dissection in the treatment of early gastric cancer and precancerous lesions

目的分析内镜黏膜下剥离术(ESD)治疗早期胃癌与癌前病变的临床效果。方法将80例早期胃癌及癌前病变患者随机分为两组,各40例。对照组接受保守治疗,研究组在对照组基础上接受ESD治疗。比较两组临床疗效、并发症发生率、复发率和生活质量评分。结果研究组临床总有效率高于对照组(P<0.01),并发症发生率和复发率均低于对照组(P<0.01);手术3个月后两组患者生活质量各项评分均高于手术前(P<0.05),研究组手术后3个月生活质量各项评分均高于对照组(P<0.01)。结论 ESD治疗早期胃癌与癌前病变的临床效果优于保守治疗方法,可减少并发症的发生率和复发率,提高患者的生活质量,改善患者的预后。

Objective To investigate the clinical efficacy of endoscopic submucosal dissection(ESD)in the treatment of early gastric cancer and precancerous lesions.Methods Eighty patients with early gastric cancer or precancerous lesions were randomly divided into two groups,each with forty cases.The control group received expectant treatment,while the research group received ESD treatment on the basis of the control group.The clinical efficacy,complication rate,recurrence rate and quality of life score were compared between the two groups.Results The total clinical effective rate of the research group was higher than that of the control group(P<0.01),and the complication rate and recurrence rate were lower than those of the control group(P<0.01).Three months after the operation,the quality of life scores of the two groups were higher than those before the operation(P<0.05),and the quality of life scores of the research group were higher than those of the control group(P<0.01).Conclusion The clinical effect of ESD in the treatment of early gastric cancer and precancerous lesions is better than conservative treatment methods,which can reduce the incidence of complications and the recurrence rate,improve the quality of life of patients,and improve the prognosis of patients.