八宝丹联合熊去氧胆酸胶囊治疗原发性胆汁性肝硬化临床观察

Clinical Observation on Babao Mini-pills Combined with Ursodeoxycholic Acid Capsules in the Treatment of Primary Biliary Cirrhosis

目的观察八宝丹联合熊去氧胆酸胶囊治疗原发性胆汁性肝硬化的临床疗效。方法将60例原发性胆汁性肝硬化患者随机分为2组。对照组30例单用熊去氧胆酸胶囊治疗,治疗组30例在对照组基础上加用八宝丹,2组疗程均为1年。观察2组治疗后临床症状、肝功能指标、肝纤维化指标变化情况。结果疗程结束后,2组临床症状、肝功能、肝纤维化指标均较治疗前明显改善(P均<0.05),且治疗组效果明显优于对照组(P均<0.05)。结论八宝丹联合熊去氧胆酸胶囊治疗原发性胆汁性肝硬化效果好,值得临床推广。

Objective To observe the cilnical efficacy of Babao mini-pills combined with ursodeoxycholic acid capsules(UDCAC)in treating patients with primary biliary cirrhosis(PBC).Methods 60 patients with primary biliary cirrhosis were randomly divided into 2 groups,30 patients in the control group were treated with ursodeoxycholic acid alone,and 30 cases in the treatment group were treated with Babao mini-pills on the basis of treatment of control group.The course of treatment in both groups was 1 year.The changes of clinical symptoms,liver function indexes and liver fibrosis indexes in the 2 groups after treatment were observed.Results After the course of treatment,the clinical symptoms,liver function and liver fibrosis indexes in the two groups were significantly improved compared with those before treatment(all P<0.05),and the therapeutic effect of the treatment group was significantly better thanthat of the control group(all P<0.05).Conclusion Babao mini-pills combined with ursodeoxycholic acid capsules are effective in treating PBC,and is worthy of clinical promotion.