普米克令舒联合特布他林在支气管扩张中的治疗作用观察

Therapeutical effect obeservation of Pulmicort Respules combined with Terbutaline in bronchiectasis

目的观察吸入用布地奈德混悬液(普米克令舒)联合特布他林在支气管扩张中的治疗作用。方法选取2016年2月~2019年10月萍乡市人民医院收治的60例支气管扩张患者作为研究对象,采用随机数字表法将其分为对照组和观察组,每组各30例。对照组采用常规药物治疗,观察组采用普米克令舒联合特布他林治疗。治疗7 d后,比较两组患者的临床疗效、临床症状评分(包括咳嗽、咳痰量、痰液黏稠)、炎症标志物[C反应蛋白(CRP)、降钙素原(PCT)、纤维蛋白原]水平及住院时间。结果观察组患者的治疗总有效率(93.33%)高于对照组(73.33%),差异有统计学意义(P<0.05)。观察组患者的咳嗽、咳痰量、痰液黏稠评分均低于对照组,差异有统计学意义(P<0.05)。观察组患者的CRP、PCT及纤维蛋白原水平均低于对照组,差异有统计学意义(P<0.05)。观察组患者的住院时间短于对照组,差异有统计学意义(P<0.05)。结论普米克令舒联合特布他林治疗支气管扩张效果显著,可以有效改善患者的临床症状,消除炎症,缩短住院时间。

Objective To observe the therapeutical effect of Budesonide Suspension for Inhalation(Pulmicort Respules)combined with Terbutaline in bronchiectasis.Methods A total of 60 patients with bronchiectasis who were admitted to People′s Hospital of Pingxiang City from February 2016 to October 2019 were selected as the research objects and divided into the control group and the observation group by random number table method,with 30 cases in each group.The control group was treated with routine medicine,and the observation group was treated with Pulmicort Respules combined with Terbutaline.The clinical efficacy,scores of clinical symptoms(cough,sputum volume,viscous sputum),the levels of inflammatory markers(C-reactive protein[CRP],procalcitonin[PCT],fibrinogen)and length of hospital stay were compared between the two groups after 7 d of treatment.Results The total effective rate of the observation group(93.33%)was higher than that of the control group(73.33%),and the difference was statistically significant(P<0.05).The scores of cough,sputum volume and viscous sputum of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The levels of CRP,PCT and fibrinogen in the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The length of hospital stay of the observation group was shorter than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The effect of Pulmicort Respules combined with Terbutaline in treatment of patients with bronchiectasis was significant,it can improve the clinical symptoms,eliminate the inflammation,and shorten the length of hospital stay.