低分子肝素钙改善胎盘循环治疗妊娠中晚期羊水过少的临床研究

Clinical study of Low Molecular Weight Heparin Calcium to improve placental circulation in the treatment of oligohydramnios

目的探讨低分子肝素钙改善胎盘循环治疗妊娠中晚期羊水过少的临床效果。方法选取2018年1月~2019年9月我院治疗的80例妊娠中晚期羊水过少患者,采用单双抽签方式分组,单数为对照组(n=40),双数为观察组(n=40)。对照组采用静脉补液治疗,观察组在上述的基础上增加小剂量低分子肝素钙治疗,比较两组治疗前后的羊水指数(AFI)及脐动脉血流S/D值、分娩方式以及妊娠结局与分娩结局。结果观察组的AFI高于对照组,差异有统计学意义,观察组的脐动脉血流S/D值低于对照组,观察组的早产率、剖宫产率及Apgar评分≤7分率低于对照组,差异均有统计学意义(P<0.05)。观察组的新生儿体重高于对照组,差异有统计学意义(P<0.05)。结论对妊娠中晚期产妇羊水过少临床治疗采用低分子肝素钙可有效提高患者AFI,同时降低脐动脉血流S/D值,改善母婴结局,值得临床应用。

Objective To investigate the clinical effect of Low Molecular Weight Heparin Calcium on the treatment of oligohydramnios in pregnancy.Methods A total of 80 patients with oligohydramnios in the middle and late stages of pregnancy who were treated in our hospital from January 2018 to September 2019 were selected and divided by single and double drawing.The singular was the control group(n=40),the even number was the observation group(n=40).The control group was treated with intravenous fluid replacement,the observation group was treated with low-dose Low-Molecular Weight Heparin Calcium on the basis of the control group,amniotic fluid index,S/D value of umbilical artery blood flow,delivery mode and pregnancy outcome,delivery outcome before and after treatment were compared between the two groups.Results The amniotic fluid index in the observation group was higher than that in the control group,the S/D value of umbilical artery blood flow in the observation group was lower than that in the control group,the preterm birth rate,cesarean section rate and Apgar score≤7 in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The neonatal weight in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion Low Molecular Weight Heparin Calcium can effectively improve the S/D value of umbilical artery blood flow AFI,improve the outcome of maternal and infant.