玻璃体腔注射雷珠单抗注射液治疗眼底病的效果

Effect of intravitreal injection of Ranibizumab on treatment of ocular fundus disease

目的研究玻璃体腔注射雷珠单抗注射液治疗眼底病的效果。方法选取2018年1月~2019年10月我院收治的100例眼底病患者作为研究对象,采用随机数字表法将其分为对照组与观察组,每组各50例。对照组患者采用常规药物治疗,观察组患者采用常规药物加玻璃体腔注射雷珠单抗注射液治疗。比较两组患者的治疗总有效率、症状消失时间、临床症状改善情况以及血流动力学指标。结果观察组患者的治疗总有效率为92.00%,高于对照组的72.00%,差异有统计学意义(P<0.05)。观察组患者的视网膜水肿消失时间、恢复正常视网膜厚度时间、视网膜出血消失时间、新生血管消失时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者的视力高于对照组,眼压和视网膜厚度均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者的全血黏度、血浆黏度、血细胞比容和红细胞聚集指数均低于对照组,差异有统计学意义(P<0.05)。结论针对眼底病患者,采取玻璃体腔注射雷珠单抗注射液治疗,效果显著,适宜临床应用推广。

Objective To investigate the effect of intravitreal injection of Ranibizumab on treatment of ocular fundus disease.Methods A total of 100 patients with ocular fundus disease treated in our hospital from January 2018 to October 2019 were selected as the research subjects and divided into the control group and the observation group by random number table method,with 50 cases in each group.Patients in the control group were treated with conventional drugs,while patients in the observation group were treated with intravitreal injection of Ranibizumab on the basis of conventional drugs.The total effective rate,symptom disappearance time,clinical symptom improvement and hemodynamic indicators were compared between the two groups.Results The total effective rate in the observation group(92.00%)was higher than that of the control group(72.00%),and the difference was statistically significant(P<0.05).The retinal edema disappearance time,normal retinal thickness recovery time,retinal hemorrhage disappearance time and neovascularity disappearance time of the observation group were shorter than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the eyesight of the observation group was higher than that of the control group,the intraocular pressure and retinal thickness of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the whole blood viscosity,plasma viscosity,hematocrit and red blood cell aggregation index of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).Conclusion Intravitreal injection of Ranibizumab has a significant effect on treatment of ocular fundus disease and is worthy of clinical application and promotion.