n-3多不饱和脂肪酸对心房颤动的影响及机制

Effect and mechanism of n-3 polyunsaturated fatty acids on atrial fibrillation

n-3多不饱和脂肪酸是一种具有生物活性的化合物,可降低血浆三酰甘油,调节心率和血压,并具有潜在的抗心律失常作用。心房颤动(房颤)是最常见的持续性心律失常,可导致心房结构和功能的改变。近年来,研究表明n-3多不饱和脂肪酸可影响细胞膜的理化性质,调节细胞膜通道蛋白的相互作用以及转录因子的表达,从而影响心肌细胞电生理特性,并通过调节细胞膜离子通道功能而减轻心房电重构,从而直接或间接地发挥抗房颤作用。

As bioactive compounds,n-3 polyunsaturated fatty acids(n-3 PUFAs)contribute to human health through lowering serum triglyceride,and regulating heart rate and blood pressure.They also have potential anti-arrhythmia effect.Atrial fibrillation(AF)is the most commonly-seen sustained arrhythmia,which could lead to changes in atrial structure and function.In recent years,many studies have shown that n-3 PUFAs can affect the physicochemical properties of myocardial cell membranes,regulate the interaction of membrane channel proteins and the expression of transcription factors,and thus influence the electrophysiological characteristics of myocardial cells.Additionally,n-3 PUFAs play a direct or indirect anti-AF role by regulating the function of ion channels in the cell membranes and thus reducing atrial electrical remodeling.