保肾康对慢性肾小球肾炎患者肾血流动力学和肾功能的影响

Effects of Piperazine Ferulate Tablets on Hemodynamics and Renal Function in Patients with Chronic Glomerulonephritis

目的:探究保肾康对慢性肾小球肾炎(CNG)患者肾血流动力学和肾功能的影响。方法:选取2016年1月至2018年5月连云港市第二人民医院收治的CNG患者86例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组43例。对照组采用常规西药治疗,观察组在对照组基础上加用保肾康治疗。比较治疗前后2组患者总有效率、肾功能、血压及血流变学指标。结果:观察组总有效率为88.37%,显著高于对照组(69.77%,P<0.05)。治疗后,观察组收缩压和舒张压较治疗前降低(P<0.05),组间比较,差异无统计学意义(P>0.05)。治疗后,2组的纤维蛋白原和血栓素B2(TXB2)水平较治疗前降低(P<0.05),观察组低于对照组;2组6-酮-前列腺素(6-Keto-PCF1a)较治疗前升高,且观察组高于对照组(P<0.05)。2组Scr、BUN和24 h尿蛋白定量较治疗前降低,观察组显著低于对照组(P<0.05)。结论:保肾康联合常规西药治疗CNG患者,能够改善肾功能及血流动力学,降低患者血压,值得临床推广。

Objective:To explore the effects of piperazine ferulate tablets on hemodynamics and renal function of patients with chronic glomerulonephritis(CNG).Methods:A toal of 86 CNG patients admitted to Nephrology Department of Second People′s Hospital were selected as the research objects and were randomly divided into an observation group and a control group,with 43 cases in each group.The control group was treated with conventional Western medicine,while the observation group was treated with piperazine ferulate tablets on the basis of the control group.The total effective rate,renal function,blood pressure and hemorheology indexes of the 2 groups before and after treatment were compared.Results:The total effective rate of the observation group was 88.37%,significantly higher than that of the control group(69.77%,P<0.05).After treatment,systolic blood pressure and diastolic blood pressure in the observation group were lower than before treatment(P<0.05).There was no significant difference between the 2 groups(P>0.05).After treatment,the levels of fibrinogen and thromboxane B2(TXB2)in the 2 groups were lower than those before treatment(P<0.05),and the those in the observation group were lower than those in the control group.The level of 6-keto-prostaglandin(6-Keto-PCF1a)in the 2 groups was higher than that before treatment,and that in the observation group was higher than that in the control group(P<0.05).Scr,BUN and 24 h urine protein in the 2 groups were lower than those before treatment,and the observation group was significantly lower than the control group(P<0.05).Conclusion:Piperazine ferulate tablets combined with conventional Western medicine in the treatment of CNG patients can improve renal function and hemodynamics,reduce blood pressure of patients,and is worthy of clinical promotion.