氧化型低密度脂蛋白受体在动脉粥样硬化发病机制中的作用

Role of receptors for oxidized low-density lipoprotein in pathogenesis of atherosclerosis

动脉粥样硬化(atherosclerosis,AS)引起的冠心病、脑梗死和外周血管病等疾病,已成为全世界范围内人口死亡的首要原因[1],同时也是以脂质代谢紊乱、内皮不完整、单核-巨噬细胞增生及斑块形成为主要病理特征的慢性疾病[2]。在AS病变演化历程中,氧化型低密度脂蛋白(oxidized low-density lipo⁃protein,oxLDL)作为关键分子[3],与受体结合后,刺激单核-巨噬细胞摄取大量oxLDL,转变为泡沫细胞,产生大量炎性因子,启动一系列炎症反应,从而推动AS的发展。过去的十几年,学者们对AS的探讨与研究逐渐增多,循环血液中oxLDL作为与AS有关的循环生物标志物,已被列为许多急性或慢性炎性疾病的独立危险因素。

The formation of atherosclerosis(AS)is an evolutionary process.It undergoes lipid deposition,focal fibrosis in the intima of the arteries and atherosclerotic plaque formation,resulting in hardening of the vessel wall and stenosis of the lumen,which eventually leads to ischemic changes in the corresponding organs.In these processes,oxidized low-density lipoprotein(oxLDL),an oxidative product of low-density lipoprotein,is considered to be a key trigger for AS development.In this paper,the role of the receptors for oxLDL in the development of AS is reviewed based on the recent studies.