中性粒细胞与淋巴细胞比值对终末期肾病行血液透析患者感染的影响

Effect of neutrophil-lymphocyte ratio on infection of hemodialysis patients with end-stage renal disease

[目的]探究中性粒细胞与淋巴细胞比值对终末期肾病行血液透析患者感染的影响及血液透析患者感染的相关因素。[方法]选取2015年1月至2020年4月于某院接受治疗血液透析的176例终末期肾病患者为研究对象,根据患者是否发生感染将患者分为2组,其中81例发生感染的患者为观察组,95例未发生感染的患者为对照组。比较2组患者年龄、性别、糖尿病史、高血压史、血红蛋白、白蛋白、血钾、矫正血钙、血磷、血镁、三酰甘油、总胆固醇、中性粒细胞与淋巴细胞比值、超敏C反应蛋白等指标水平;探究以上指标与患者感染之间的相关关系;使用logistics多因素回归分析探究终末期肾病行血液透析患者发生感染的回归因素;统计感染患者病原菌菌种及分布情况。[结果]观察组患者血清白蛋白、矫正血钙、血磷、血镁、中性粒细胞与淋巴细胞比值以及超敏C反应蛋白比较数据具有统计学意义P<0.05。以上指标与患者发生感染的相关关系比较发现,中性粒细胞与淋巴细胞比值、血清白蛋白、血镁、矫正血钙、血磷以及超敏C反应蛋白与患者感染具有明显的相关性,数据比较差异具有统计学意义P<0.05。logistics多因素回归分析显示终末期肾病行血液透析患者发生感染受多种因素影响,中性粒细胞与比值、血清白蛋白、血镁以及超敏C反应蛋白是终末期肾病行血液透析患者发生感染的危险因素。感染患者病原菌统计发现病原菌以革兰阴性菌和革兰阳性菌为主。[结论]中性粒细胞与淋巴细胞比值与终末期肾病行血液透析患者发生感染有密切关系,是患者发生感染的危险因素,临床可对此加以控制以降低患者感染率。

[Objective]To investigate the effect of neutrophil-lymphocyte ratio on the infection of hemodialysis patients with end-stage renal disease and the related factors of hemodialysis patients. [Methods]A total of 176 patients underwent hemodialysis with end-stage renal disease in a hospital from January 2015 to April 2020 were enrolled. The patients were divided into two groups according to whether the patient developed infection. Among them, 81 patients were infected. In the observation group, 95 patients who did not have an infection were in the control group. Comparison of age, gender, history of diabetes, history of hypertension, hemoglobin, albumin, serum potassium, corrected serum calcium, blood phosphorus, magnesium, triglyceride, total cholesterol, neutrophil to lymphocyte ratio, high-sensiticity C-reactive protein and other indicators were studied;explored the correlation between the above indicators and patient infection;use logistic multi-factor regression analysis to explore the regression factors of end-stage renal disease in hemodialysis patients;statistics on the pathogens and distribution of infected patients were studied.[Results]The serum albumin, corrected serum calcium, serum phosphorus, magnesium, neutrophil to lymphocyte ratio and high-sensitivity C-reactive protein in the observation group were statistically significant(P<0.05). The correlation between the above indicators and the infection of patients found that neutrophil to lymphocyte ratio, serum albumin, blood magnesium, corrected blood calcium, blood phosphorus and high-sensitivity C-reactive protein have significant correlation with patient infection, data The difference was statistically significant(P<0.05). Multivariate regression analysis of logistics showed that infection in hemodialysis patients with end-stage renal disease was affected by many factors. Neutrophil and ratio, serum albumin, blood magnesium and high-sensitivity C-reactive protein were infections in hemodialysis patients with end-stage renal disease. The risk factor.The pathogens of infected patients were found to be mainly Gram-negative bacteria and Gram-positive bacteria. [Conclusion]The ratio of neutrophil to lymphocyte is closely related to the infection of hemodialysis patients in end-stage renal disease. It is a risk factor for patients to be infected. The clinical control can be used to reduce the infection rate.