来曲唑联合人绒毛膜促性腺激素治疗多囊卵巢综合征的疗效观察

Efficacy of Letrozole Combined with Human Chorionic Gonadotropin in the Treatment of Polycystic Ovary Syndrome

目的:观察来曲唑联合人绒毛膜促性腺激素(HCG)治疗多囊卵巢综合征的临床疗效。方法:选取我院2018年1月—2020年1月收治的多囊卵巢综合征患者110例,采用随机数字表法分为对照组、观察组各55例。对照组予以HCG+氯米芬治疗,观察组予以HCG+来曲唑治疗。治疗结束后分析两组的促排卵效果,比较生化指标及妊娠结局。结果:观察组的成熟卵泡数、子宫内膜厚度均显著高于对照组(P<0.05);观察组的血清FSH、LH及25-羟维生素D(25-OH-VD)水平均显著高于对照组(P<0.05);观察组无多胎妊娠,自然流产率为1.82%,临床妊娠率为49.09%,其妊娠结局均优于对照组(P<0.05)。结论:HCG+来曲唑治疗多囊卵巢综合征的促排卵效果显著,可提高血清内分泌相关指标及维生素D水平,改善患者的妊娠结局。

Objective:To observe the clinical efficacy of letrozole combined with human chorionic gonadotropin(HCG)in the treatment of polycystic ovary syndrome.Methods:110 patients with polycystic ovary syndrome in our hospital from January 2018 to January 2020 were selected and randomly divided into control group and observation group with 55 cases in each group.The control group was treated with HCG+clomiphene,and the observation group was treated with HCG+letrozole.After the treatment,the ovulation induction effect of the two groups was analyzed,and the biochemical indexes and pregnancy outcome were compared.Results:The number of mature follicles and endometrial thickness in the observation group were significantly higher than those in the control group(P<0.05);the serum FSH,LH and 25-OH-VD levels in the observation group were significantly higher than those in the control group(P<0.05);there was no multiple pregnancy in the observation group,the spontaneous abortion rate was 1.82%,the clinical pregnancy rate was 49.09%,and the pregnancy outcome was better than that of the control group(P<0.05).Conclusion:HCG+letrozole treatment of polycystic ovary syndrome ovulation effect is significant,can improve serum endocrine related indicators and vitamin D levels,improve the pregnancy outcome of patients.