高致病性猪繁殖与呼吸综合征病毒自然感染与人工感染下的组织病理学观察

Histopathological Observation on Natural and Artificial Infection with HP-PRRSV

为进一步研究高致病性猪繁殖与呼吸综合征病毒(HP-PRRSV)的致病机理,对HP-PRRSV自然感染和人工感染下的病理组织学变化进行比较观察。在组织病理学变化方面,自然感染病例病变性质与人工感染基本相同,但在病变范围以及严重程度方面存在明显差异:自然感染病例的胃肠道病变尤为显著,而人工感染病例却较少引发消化道病变;自然感染病例的炎症波及全身淋巴结,而人工感染病例以肺门淋巴结、下颌淋巴结、肠系膜淋巴结病变最为明显,其他部位淋巴结未见明显病变。自然感染病例中,常见多种病原的混合感染,提示HP-PRRSV可能作为多种疾病的基础病因。自然感染和人工感染病例在肺脏上均表现为严重的间质性肺炎,说明肺脏部位的病理变化对单纯HP-PRRSV感染的诊断具有指证意义。本研究为HP-PRRSV感染的诊断及其致病机理研究提供了理论依据。

In order to further study the pathogenesis of highly pathogenic porcine reproductive and respiratory syndrome virus(HP-PRRSV),the histopathological changes of natural and artificial infection with HP-PRRSV were compared and observed.For the nature of lesions,the natural and artificial infection cases were basically similar,but obviously different in the scope and severity degree of the lesions;the gastrointestinal lesions were particularly significant in the natural infection cases,and fewer gastrointestinal lesions were observed in the artificial ones;all the lymph nodes were involved in the inflammation of the natural infection cases,but the lesions of hilar lymph nodes,mandibular lymph nodes and mesenteric lymph nodes appeared in the artificial infection cases,and other lymph nodes were normal.Mixed infection with multiple diseases were common in natural infection cases,indicating that HPPRRSV might be the general cause for several diseases.Severe interstitial pneumonia was shown in the lungs of both natural and artificial infection cases,which indicated that the pathological changes of the lungs were indicative for the diagnosis of single infection with HP-PRRSV.As a conclusion,a theoretical basis was provided for the diagnosis of HP-PRRSV infection and for the study on its pathogenesis.