富血小板血浆局部注射治疗雄激素性脱发的疗效及安全性系统评价

Systematic review of the efficacy and safety of platelet-rich plasma injection in the tratment of androgenetic alopecia

目的:对富血小板血浆局部注射治疗雄激素脱发的有效性及安全性进行评价。方法:计算机检索截至2020年5月的Pubmed、Embase、the Cochrane library、Web of science、中国知网(CNKI)、中国生物医学文献服务系统、万方数据库、维普中文科技期刊全文数据库中关于富血小板血浆治疗雄激素脱发的随机对照试验,经2名医生筛选纳入文献并进行文献评价,最后对纳入文献进行分析,采用Revman 5.3软件进行meta分析。结果:纳入10个文献,212例患者。meta分析显示:(1)富血小板血浆注射可增加毛发密度,与安慰剂组比较差异有显著性(WMD=29.39,95%CI=1.89~56.89,P=0.04)。(2)局部暂时疼痛是主要的不良事件,其它少见的不良事件包括:出血、瘀斑、水肿等,无严重不良反应发生。结论:富血小板血浆局部注射有利于改善毛发密度,未发现严重不良反应。

Objective:To evaluate the efficacy and safety of platelet-rich plasma injection in the treatment of androgenetic alopecia.Methods:The randomized controlled trials on platelet-rich plasma injection in the treatment of androgenetic alopecia were searched in CNKI,Wanfang Database,CQVIP,Sinomed Database,Pubmed,Cochrane Library,Embase,Web of Science from inception to May,2020.Two reviewers screened literature,extracted data,and assessed risk bias of included researches.Meta-analysis was performed by RevMan 5.3 software.Results:A total of 10 studies involving 212 patients were included.Meta-analyses showed that the hair density of was higher in the patients treated with platelet-rich plasma than in control group,(WMD=29.39,95%CI=1.89-56.89,P=0.04).The most common adverse reaction was pain,followed by erythema,ecchymosis and edema.There were no serious adverse events in both groups.Conclusion:Platelet-rich plasma injection can improve hair density with no serious adverse events.