血栓性抗磷脂综合征相关血小板活性

Platelet activation in patients with thrombotic antiphospholipid syndrome

抗磷脂综合征(antiphospholipid syndrome,APS)是一种常见的获得性易栓症,主要临床表现为动静脉血栓形成以及反复病理妊娠。尽管有大量相关研究深入探讨APS的发病机制,但至今尚未完全阐明,目前被广泛接受的理论包括抗磷脂抗体诱导促凝状态及促炎状态,血小板活性升高导致血栓形成。血小板是血栓形成的中心环节,其表面有多种受体与抗磷脂抗体复合物相互作用,多项研究证实血小板在抗磷脂综合征患者中活性显著高于正常人。本文整理近年来有关血小板活性与血栓性抗磷脂综合征的相关证据,促进相关领域进一步深入研究。

Antiphospholipid syndrome(APS)is a kind of acquired thrombophilia characterized as arterial and/or venous thrombosis and recurrent fetal loss.The pathogenesis of APS is still unclear even with massive related studies.Theories widely accepted include antiphospholipid antibodies(aPLs)induced procoagulant and pro-inflammatory status,as well as elevated platelet activation.Platelets as the key player in the process of thrombosis contain many receptors to react with aPLs complexes.Many studies have confirmed that platelet activation in APS patients is higher than that in healthy control.Here we reviewed evidence of correlation between platelet activation and thrombosis in APS patients.