交界性卵巢肿瘤年龄分布状况及临床病理特征分析

Age distribution and clinicopathological characteristics of borderline ovarian tumors

目的探讨交界性卵巢肿瘤(borderline ovarian tumors,BOTs)患者年龄分布状况及临床病理特征。为卵巢上皮性癌的前期病变的早期发现提供流行病学资料。方法对2008年10月-2018年10月我院接受手术治疗的BOTs患者467例进行回顾性分析。探讨患者就诊年龄分布状况及各年龄段患者所占比例,对纳入研究患者的手术方式、FIGO分期、病理类型、是否存在微浸润、是否局灶癌变及卵巢累及范围等临床病理特征进行分析。分别按照以下年龄段:≤20岁、21-25岁、26-30岁、31-35岁、36-40岁、41-45岁、46-50岁、51-55岁、56-60岁、61-65岁、65-70岁、≥71岁分组,对各年龄段患者例数及所占比例进行分析。结果467例BOTs患者中,年龄≤35岁患者197例,占42.2%;年龄>35岁患者270例,占57.8%。根据组织病理类型划分,交界性黏液性肿瘤231例,交界性浆液性肿瘤119例,交界性浆-黏液性肿瘤74例,交界性子宫内膜样肿瘤27例,交界性透明细胞肿瘤6例,混合性8例,交界性Brenner瘤2例。根据手术方式不同,分为全面分期188例;保留生育功能分期术50例;双侧肿瘤剔除15例;双侧附件切除8例;全子宫+双附件切除18例;保留一侧附件的分期术8例。结论BOTS患者病理类型以交界性粘液性卵巢肿瘤为主,患者发病年轻,高峰年龄为25-40岁。

Objective To investigate the age distribution and clinicopathological characteristics of borderline ovarian tumors(BOTs).To provide epidemiological data for early detection of precancerous lesions of epithelial ovarian cancer.Methods 467 patients with BOTs who underwent surgical treatment in Jiangxi Maternal and Child Health Hospital from October 2008 to October 2018 were retrospectively analyzed.To explore the age distribution of patients and the proportion of patients in different age groups,and to analyze the clinicopathological characteristics of patients included in the study,such as the operation mode,FIGO staging,pathological type,whether there is micro-infiltration,whether there is focal canceration and the range of ovarian involvement.According to the following age groups:less than 20 years old,21-25 years old,26-30 years old,31-35 years old,36-40 years old,41-45 years old,46-50 years old,51-55 years old,56-60 years old,61-65 years old,65-70 years old and over 71 years old,the number and proportion of patients in each age group were analyzed.Results Of 467 patients with BOTs,197(42.2%)were under 35 years old,and 270(57.8%)were over 35 years old.According to histopathological types,231 borderline mucinous tumors,119 borderline serous tumors,74 borderline serous-mucinous tumors,27 borderline endometrioid tumors,6 borderline clear cell tumors,8 mixed tumors and 2 borderline Brenner tumors were classified.According to different surgical methods,188 cases were divided into comprehensive stages,50 cases of fertility preservation stages,15 cases of bilateral tumor removal,8 cases of bilateral adnexal excision,18 cases of total uterus+bilateral adnexal excision,and 8 cases of unilateral adnexal preservation stages.Conclusion Borderline mucinous ovarian tumors are the main pathological type of BOTS.The onset of BOTS is younger and the peak age is 25-40 years old.