探讨艾司奥美拉唑联合奥曲肽治疗肝硬化上消化道出血的临床疗效

To Explore the Clinical Efficacy of Omeprazole Combined with Octreotide in the Treatment of Upper Gastrointestinal Bleeding in Cirrhosis

目的分析艾司奥美拉唑联合奥曲肽治疗肝硬化上消化道出血的临床疗效。方法选取定远县总医院2018年10月至2019年10月收治的96例肝硬化上消化道出血患者作为研究对象,按照随机数字表法分为对照组(48例)与观察组(48例)。对照组采用艾司奥美拉唑治疗,观察组采用艾司奥美拉唑联合奥曲肽治疗。对比两组患者的住院时间、止血时间、输血量及不良反应发生率。结果观察组患者的住院时间和止血时间均短于对照组,输血量少于对照组,组间比较差异有统计学意义(P<0.05);观察组患者的不良反应发生率与对照组比较,差异无统计学意义(P>0.05);治疗前,两组患者的血流指标并比较,差异无统计学意义(P>0.05);治疗后,观察组患者的血流指标均优于对照组,组间比较差异有统计学意义(P<0.05)。结论采用艾司奥美拉唑联合奥曲肽治疗肝硬化上消化道出血时,可有效减少出血量,提升治疗总有效率,无严重不良反应发生,有较高的临床应用价值。

Objective To analyze and discuss the clinical effect of esomeprazole combined with octreotide in the treatment of upper gastrointestinal hemorrhage in cirrhosis.Methods From October 2018 to October 2019,96 patients with upper gastrointestinal hemorrhage due to cirrhosis in Dingyuan County General Hospital.The patients were divided into control group and observation group according to the random grouping method,48 cases in each group.The control group was treated with esomeprazole while the observation group was treated with esomeprazole combined with octreotide.The length of hospital stay,hemostatic time,blood transfusion volume and incidence of adverse reactions were compared between the two groups.Results The time of hospitalization and hemostasis in the observation group was shorter than that in the control group,and the amount of blood transfusion was less than that in the control group,the difference was statistically significant(P<0.05);the adverse reaction rate in the observation group was slightly different from that in the control group There was no statistical significance(P>0.05);before treatment,there was no significant change in the blood fLow index of the two groups,and the difference was not statistically significant(P>0.05);after treatment,the blood fLow index of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Esomeprazole combined with octreotide in the treatment of liver cirrhosis upper gastrointestinal bleeding,can effectively reduce the amount of bleeding,improve the total efficiency of treatment,no serious adverse reactions,has high clinical application value.