贲门失弛缓症发病机制的研究进展

Recent progress in the pathogenesis of achalasia

贲门失弛缓症(achalasia,AC)是一种以食管体部正常蠕动消失、食管下括约肌松弛异常为特征的运动障碍性疾病。近年来这种疾病的发病率连年增加,其发病机制及治疗成为人们关注的热点,研究AC的发病机制有利于本病的治疗及预后,AC主要的发病机制包括遗传性、神经源性、免疫性、病毒感染以及精神心理或多因素共同作用,本文就关于AC的发病机制进行讨论。

Achalasia of the cardia is a movement disorder characterized by the absence of normal peristalsis of the esophagus and abnormal relaxation of the lower esophageal sphincter.In recent years,the incidence of this disease has increased yearly,and its pathogenesis and treatment have become a research focus.Studying the pathogenesis of AC is beneficial for the treatment and prognosis of this disease.Its main pathogeneses include inheritance,nerves,immunity,viral infection,and psychology or multifactorial interactions.This article discusses the pathogenesis of achalasia cardia.