新生儿肺炎诊治中检测降钙素原水平变化的临床价值

Clinical value of detecting changes of procalcitonin levels in the diagnosis and treatment of neonatal pneumonia

目的探究新生儿肺炎诊治中检测降钙素原(PCT)水平变化的临床价值。方法回顾性分析2019年7月至2019年10月本院儿科收治的90例新生儿临床资料。其中新生儿肺炎患儿60例作为研究组,并根据感染程度分为重症组与轻症组,各30例,另外30名健康新生儿作为对照组。抽取新生儿的静脉血,采用全自动化学发光分析仪检测血清中CRP及PCT水平,另采用免疫比浊法检测WBC水平。比较研究组与对照组PCT、CRP、WBC水平;比较PCT、CRP、WBC诊断新生儿肺炎的敏感度、特异性及准确度;比较重症组与轻症组的PCT水平;比较治疗前后研究组的PCT水平。结果重症组PCT水平为(10.26±5.47)ng/mL、CRP水平为(32.57±6.28)mg/L、WBC水平为(30.15±7.49)×10^9/L均高于轻症组(1.54±0.69)ng/mL、(14.63±5.22)mg/L、(14.82±6.37)×10^9/L与对照组(0.07±0.01)ng/mL、(5.14±1.06)mg/L、(6.81±0.95)×10^9/L,差异有统计学意义(P<0.05)。PCT敏感度为96.55%、特异度为90.24%、准确度为93.42%均高于CRP及WBC,差异有统计学意义(P<0.05)。重症组PCT水平为(10.26±5.47)ng/mL,高于轻症组的(1.54±0.69)ng/mL,差异有统计学意义(P<0.05)。两组治疗后PCT水平分别为(0.50±0.03)ng/mL、(0.49±0.02)ng/mL,两组比较差异无统计学意义。结论在新生儿肺炎中实时监测PCT水平变化,有助于及时判断患儿病情及预后状况,具有较高的临床应用价值。

Objective To investigate the clinical value of detecting changes in procalcitonin(PCT)levels in the diagnosis and treatment of neonatal pneumonia.Methods The clinical data of 90 neonates admitted to our hospital from July 2019 to October 2019 were retrospectively analyzed.60 children with neonatal pneumonia were treated as the study group,and they were divided into severe group and mild group according to the degree of infection,another 30 healthy infants were treated as the control group.All the venous blood of the newborns participating in the study were taken,and the serum CRP and PCT levels were detected under a fully automated chemiluminescence analyzer,and the WBC level was detected by immunoturbidimetry.The PCT,CRP,and WBC levels were compared between the study group and the control group.The sensitivity,specificity,and accuracy of PCT,CRP,and WBC in the diagnosis of neonatal pneumonia were compared.The PCT levels were compared between the septic group and the mild group,and the PCT levels of the study group before and after treatment were compared.Results The PCT level was(10.26±5.47)ng/mL,the CRP level was(32.57±6.28)mg/L,and the WBC level was(30.15±7.49)×10^9/L in the severe group,which was higher than the mild group[(1.54±0.69)ng/mL,(14.63±5.22)mg/L,(14.82±6.37)×10^9/L]and control group[(0.07±0.01)ng/mL,(5.14±1.06)mg/L,(6.81±0.95)×10^9/L],the difference was statistically significant(P<0.05).The PCT sensitivity was 96.55%,specificity was 90.24%,and accuracy was 93.42%,which was higher than CRP and WBC(P<0.05).The PCT level in the severe group was(10.26±5.47)ng/mL higher than that in the mild group(1.54±0.69)ng/mL,with significant difference(P<0.05).The PCT levels in the two groups were(0.50±0.03)ng/mL and(0.49±0.02)ng/mL,and the difference was not significant between two groups.Conclusion Real-time monitoring of changes in PCT levels in neonatal pneumonia can help determine the condition and prognosis of children in a timely manner,and has a high clinical value.