维持性血液透析患者HCV感染的危险因素及其交互作用研究

Study on the risk factors and interaction of HCV infection in maintenance hemodialysis patients

目的探究维持性血液透析(MHD)患者丙型肝炎病毒(HCV)感染的危险因素及其交互作用。方法采用整群抽样的方法,选取2018年1月至2019年12月本院收治的182例MHD患者作为研究对象,收集患者人口学资料及与HCV感染的可能性行为因素,检测患者抗-HCV、HCV RNA水平,对MHD患者HCV感染影响因素进行Logistic回归分析。结果 182例MHD患者HCV感染率为16.48%(30/182);多因素Logistic回归分析既往输血史、肾移植病史以及持续透析时间≥3年与HCV感染密切相关;既往输血史与肾移植病史存在相加交互、相乘交互作用。结论 MHD患者发生HCV感染与既往输血史、肾移植史等因素有关,且既往输血史与肾移植病史具有交互作用,应给予高度重视。

Objective To explore the risk factors and interaction of hepatitis C virus(HCV)infection in maintenance hemodialysis(MHD)patients.Methods By cluster sampling,182 MHD patients in our hospital from January 2018 to December 2019 were selected as the study subjects.The demographic data and the possible behavioral factors of HCV infection were collected,the anti HCV and HCV RNA levels were detected,and the influencing factors of HCV infection in MHD patients were analyzed by logistic regression.Results In 182 MHD patients,the rate of HCV infection was 16.48%(30/182).Through multivariate logistic regression analysis,it was found that the history of previous blood transfusion,renal transplantation and continuous dialysis time≥3 years were closely related to HCV infection.There were additive interaction and multiplicative interaction between the history of previous blood transfusion and the history of renal transplantation.Conclusion HCV infection in MHD patients is related to the history of blood transfusion and renal transplantation,and the history of blood transfusion and renal transplantation have interaction,so we should pay more attention to it.