银翘散加减治疗肾移植术后上呼吸道感染的临床疗效观察

Clinical observation of Yinqiaosan addition and subtraction on patients with upper respiratory tract infection after renal transplantation

目的探讨银翘散加减治疗肾移植术后上呼吸道感染的临床疗效,并观察其对患者炎症指标及免疫功能指标的影响。方法选取2018年1月至2020年1月本院收治的80例肾移植术后上呼吸道感染患者作为研究对象,以入院病例号为编号根据随机数字表法分为对照组与观察组,每组40例。对照组按照常规西医对症处理;观察组在对照组基础上给予银翘散加减治疗,每天1剂。观察比较两组发热持续时间(从发热到体温恢复正常)、住院天数、白细胞计数(WBC)、中性粒细胞比率(NE%)、C反应蛋白(CRP)、降钙素原(PCT)、血肌酐(SCR)、尿素氮(BUN)、免疫功能指标。结果治疗后,两组各项中医证候评分均显著降低(P<0.05),且观察组各项中医证候评分均显著低于对照组(P<0.05);观察组总有效率高于对照组(P<0.05);观察组发热持续时间和出院天数均短于对照组(P<0.05);治疗后,观察组WBC、NE%、CRP明显低于对照组(P<0.05),两组PCT、SCR、BUN水平比较差异无统计学意义;治疗前后,两组外周血CD4^+、CD8^+、CD4^+/CD8^+水平比较差异无统计意义。结论银翘散加减治疗肾移植术后上呼吸道感染具有一定临床疗效,可降低患者炎症指标,缩短病程,对免疫功能指标无明显影响。

Objective To investigate the clinical effect of Yinqiaosan addition and subtraction on upper respiratory tract infection after renal transplantation,and to observe its influence on patients'inflammation and immune function indexes.Methods 80 patients with upper respiratory tract infection after renal transplantation in our hospital from January 2018 to January 2020 were selected as the study subjects,and they were divided into control group and observation group according to the random number table method,with 40 cases in each group.The control group was treated symptomatically with conventional western medicine.The observation group was given Yinqiao powder plus or minus treatment at the same time,one dose per day.The duration of fever(from fever to normal body temperature),length of hospital stay,white blood cell count(WBC),neutrophil ratio(NE%),C-reactive protein(CRP),procalcitonin(PCT),Blood creatinine(SCR),urea nitrogen(BUN),and immune function indicators were observed and compared.Results The scores of TCM syndromes in the two groups were significantly reduced after treatment(P<0.05),and the scores of TCM syndromes in the observation group were significantly lower than those in the control group(P<0.05).The total effective rate of the observation group was higher than that of the control group(P<0.05);the fever duration and discharge days of the observation group were shorter than those of the control group(P<0.05).After treatment,WBC,NE%,and CRP in the observation group were significantly lower than those in the control group(P<0.05).There was no statistical difference in PCT,SCR,and BUN levels between the two groups.There was no statistically significant difference in the levels of CD4+,CD8+,and CD4+/CD8+in peripheral blood between the two groups of patients before and after treatment.Conclusion Yinqiaosan addition and subtraction treatment of upper respiratory tract infection after renal transplantation has a certain clinical effect,it can reduce patients'inflammation indicators,shorten the course of disease,and have no significant effect on immune function indicators.