CT指导下介入治疗中晚期肝癌的疗效及对患者应激反应和情绪的影响

Effect of CT-guided interventional therapy on stress response and emotion in patients with advanced hepatocellular carcinoma

目的探讨CT指导下介入治疗中晚期肝癌的近期疗效及对患者应激反应和情绪的影响。方法选取本院2018年2月至2019年1月收治的原发性中晚期肝癌患者68例作为研究对象,随机分为观察组与对照组,各34例。观察组采用64排CT指导下TACE介入治疗,对照组采用16排CT指导下TACE介入治疗。比较两组患者近期疗效及治疗3个月后应激反应水平及情绪变化情况。结果观察组总有效率为64.71%,高于对照组的35.29%(P<0.05)。观察组病情控制率为82.35%,高于对照组的73.53%,但差异无统计学意义。治疗前,两组PSSH及LOT-R评分比较差异无统计学意义;治疗3个月后,两组PSSH评分均降低,LOT-R评分均升高(P<0.05),观察组PSSH评分低于对照组,LOT-R评分高于对照组(P<0.05)。结论 CT指导下介入治疗可明显降低中晚期肝癌患者术后应激水平,提高乐观情绪,明显提高患者近期疗效,可进行应用和推广。

Objective To investigate the short-term efficacy of CT-guided interventional therapy for advanced hepatocellular carcinoma(HCC)and its effect on stress response and emotion of patients.Methods 68 patients with advanced primary hepatocellular carcinoma admitted to our hospital from February 2018 to January 2019 were selected as study subjects.They were randomly divided into control group and observation group,with 34 cases in each group.The observation group was treated with TACE under the guidance of 64-slice CT,while the control group was treated with TACE under the guidance of 16-slice CT.The short-term curative effect,stress response level and emotional changes after 3 months of treatment were compared between the two groups.Results The total effective rate of the observation group was 64.71%which was higher than that of the control group 35.29%(P<0.05).The disease control rate of the observation group was 82.35%,which was higher than 73.53%of the control group,but the difference was not statistically significant.There was no significant difference in PSSH and LOT-R scores between the two groups before treatment.After 3 months of treatment,PSSH score of both groups decreased,but LOT-R score increased(P<0.05),and the PSSH score of the observation group was lower than that of the control group,and the LOT-R score was higher than that of the control group(P<0.05).Conclusion CT-guided interventional therapy can significantly reduce the post-operative stress level of patients with advanced hepatocellular carcinoma,improve optimism,and improve the short-term efficacy of patients,which can be applied and promoted.