右美托咪定在创伤性脑损伤患者镇静治疗中的影响分析

Analysis of the Effect of Dexmedetomidine on Sedation in Patients with Traumatic Brain Injury

目的;对右美托咪定在创伤性脑损伤(TBI)患者镇静治疗中的影响进行分析。方法:128例创伤性脑损伤患者,按照随机数字表随机分为右美托咪定组(n=64)和冬眠合剂组(n=64例),对两组患者的催眠深度、镇静程度、谵妄发生状况及生命体征进行对比与分析。结果:用药后试验组BIS值及Ramsay评分皆优于对照组,差异有统计学意义(P<0.05);试验组谵妄发生率远低于对照组,差异有统计学意义(P<0.05),试验组心率和血压低于对照组,差异有统计学意义(P<0.05)。结论:右美托咪定在TBI患者的镇静治疗中能够有效增加患者镇静程度,增加催眠深度,降低患者谵妄发生率,值得于临床领域进行广泛推广与使用。

Purpose;To analyze the effect of dexmedetomidine on sedation in patients with traumatic brain injury(TBI).Methods:128 patients with traumatic brain injury were randomly divided into dexmedetomidine group(n=64)and Hibernation mixture group(n=64)according to random Numbers.Results:BIS values and Ramsay scores in the experimental group were better than those in the control group,and the differences were statistically significant(P<0.05).The incidence of spectral errors in the experimental group was far lower than that in the control group,with statistically significant differences(P<0.05).The heart rate and blood pressure in the experimental group were lower than that in the control group,with statistically significant differences(P<0.05).Conclusion:Dexmedetomidine in the sedation treatment of TBI patients can effectively increase the degree of sedation,increase the depth of hypnosis,reduce the incidence of spectral inaccuracy in patients,and is worthy of extensive promotion and use in the clinical field.