脑小血管病患者血Hcy、hs-CRP水平与认知功能障碍的相关性分析

Correlation analysis of serum Hcy and hs-CRP levels and cognitive dysfunction in patients with cerebral small vessel disease

目的分析脑小血管病患者血同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)水平与患者认知功能障碍的相关性。方法选取脑小血管病患者72例,分为认知功能正常组(36例)和认知功能障碍组(36例),选取同期健康体检36例作为对照组。比较3组的一般资料、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、甘油三酯(TG)、总胆固醇(TC)、肌酐(Cr)、尿酸(UA)、蒙特利尔评估量表(MoCA)评分、Hcy及hs-CRP的水平,并分析MoCA评分与血Hcy、hs-CRP水平的相关性。结果 3组的HDL、LDL、TG、TC、Cr、UA等水平差异无统计学意义(P>0.05);认知功能正常组、认知功能障碍组的MoCA评分及Hcy水平低于对照组(P<0.01),hs-CRP水平高于对照组(P<0.01),认知功能障碍组的Hcy、hsCRP水平高于认知功能正常组(P<0.01),MoCA评分低于认知功能正常组(P<0.01);MoCA评分中的视结构、执行功能、计算力、注意力、MoCA总分与血Hcy、hs-CRP水平呈负相关(P<0.01)。结论血Hcy、hs-CRP水平与脑小血管病患者的认知功能障碍有关,对脑小血管病患者进行Hcy、hs-CRP水平的检测,有助于评估患者的认知功能。

Objective To analyze the correlation between serum homocysteine(Hcy)and high-sensitivity C-reactive protein(hs-CRP)levels and cognitive dysfunction in patients with cerebral small vessel disease.Methods A total of 72 patients with cerebral small vessel disease were divided into the Normal Function Group and Dysfunction Group,36 cases in each Group.At the same time,36 healthy persons receiving physical examination were selected as the Control Group.The three groups were compared in terms of general information,high-density lipoprotein(HDL),low-density lipoprotein(LDL),triglyceride(TG),total cholesterol(TC),creatinine(Cr),and uric acid(UA)levels,Montreal Cognitive Assessment(MoCA)score,and Hcy and hs-CRP levels.The correlation between MoCA score and serum Hcy level,and that between MoCA score and serum hs-CRP level were analyzed.Results There was no statistical difference in the HDL,LDL,TG,TC,Cr,and UA levels among the three Groups(P>0.05);The Normal Function Group and the Dysfunction Group had the MoCA score and Hcy level lower than the Control Group(P<0.01),and had the hs-CRP level higher than the Control Group(P<0.01);the Dysfunction Group had the Hcy level and hs-CRP level higher than the Normal Function Group(P<0.01),but had the MoCA score lower than the Normal Function Group(P<0.01).The visual structure,executive function,computational power and attention in the MoCA score and total MoCA score were negatively correlated with serum Hcy and hs-CRP levels(P<0.01).Conclusion Serum Hcy and hs-CRP levels are related to cognitive dysfunction in patients with cerebral small vessel disease.The detection of Hcy and hs-CRP levels in patients with cerebral small vessel disease is helpful to evaluate the cognitive function of patients.