紫杉醇脂质体联合调强放疗治疗老年中晚期宫颈癌37例临床观察

Clinical efficacy of paclitaxel liposome and intensity-modulated radiotherapy in elderly patients with advanced cervical cancer

目的了解紫杉醇脂质体联合调强放疗治疗老年中晚期宫颈癌的效果和安全性。方法 74例老年中晚期宫颈癌患者随机分为对照组和观察组,每组37例。对照组采用顺铂周疗联合调强放疗治疗方案,观察组采用紫杉醇脂质体周疗联合调强放疗治疗方案。对比两组的近期疗效、疾病控制率和不良反应发生情况。结果观察组近期疗效、疾病控制率均明显优于对照组(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论紫杉醇脂质体联合调强放疗可提高老年中晚期宫颈癌近期疗效,安全性高。

Objective To observe the clinical efficacy and safety of paclitaxel liposome and intensity-modulated radiotherapy(IMRT)in elderly patients with advanced cervical cancer(ACC).Methods Seventy-four elderly patients with ACC were randomly treated with paclitaxel liposome and IMRT(observation group,n=37)or cisplatin and IMRT(control group,n=37).Short-term efficacy,disease control rate,and adverse reactions were compared between two groups.Results Short-term efficacy and disease control rate were better in observation group than in control group(P<0.05),but there was no significant difference in adverse reactions between two groups(P>0.05).Conclusion Combined paclitaxel liposome and IMRT can improve short-term efficacy and have good safety in elderly patients with ACC.