小剂量阿司匹林对高危妊娠期高血压疾病患者发病率与凝血功能的影响

Effect of low-dose aspirin on morbidity and coagulation function in high-risk pregnancy-induced hypertension

目的探讨小剂量阿司匹林治疗高危妊娠期高血压疾病对患者发病率及凝血功能的影响。方法选取2017年9月-2019年9月广东医科大学附属第二医院收治的高危妊娠期高血压疾病患者82例,按随机数字表法分为两组,各41例。对照组予以安慰剂治疗,观察组采用小剂量阿司匹林治疗。比较两组妊娠期高血压疾病发病率、凝血功能指标及不良反应发生状况。结果观察组妊娠期高血压疾病发病率为19.51%,低于对照组的41.46%,差异有统计学意义(P<0.05);治疗前,两组凝血功能指标相比,差异无统计学意义(P>0.05);观察组治疗后D-二聚体(D-D)、血浆纤维蛋白原(FIB)为(0.78±0.13)mg/L、(3.85±0.43)g/L,低于对照组的(1.24±0.31)mg/L、(5.06±1.04)g/L,凝血酶原时间(PT)、凝血酶时间(TT)及部分凝血活酶时间(APTT)为(12.24±1.59)s、(18.33±3.56)s、(32.83±5.49)s,长于对照组的(9.86±1.83)s、(15.22±3.67)s、(28.11±5.04)s,差异有统计学意义(P<0.05);两组均未出现严重不良反应。结论小剂量阿司匹林可降低高危妊娠期高血压疾病患者发病率,改善凝血功能指标,且不良反应少,安全可靠。

Objective To investigate the effects of low-dose aspirin on high-risk pregnancy-induced hypertension(pregnancy-induced hypertension) on the incidence and coagulation function of patients. Methods A total of 82 patients with high-risk pregnancy-induced hypertension who were admitted to the second affiliated hospital of Guangdong Medical University from September 2017 to September 2019 were selected and divided into two groups according to the random number table method, with 41 cases in each group. The control group was treated with placebo, and the observation group was treated with low-dose aspirin. The incidence of pregnancy-induced hypertension, blood coagulation function indexes, and the adverse reactions were compared between the two groups. Results The incidence of pregnancy-induced hypertension in the observation group was 19.51%, which was lower than41.46% in the control group, and the difference was statistically significant(P < 0.05). Before treatment, there was no statistically significant difference in the coagulation function indicators between the two groups(P > 0.05);D-dimer(DD)and plasma fibrinogen(FIB)in the observation group after treatment were(0.78±0.13)mg/L and(3.85±0.43)g/L, which were lower than those in the control group(1.24±0.31)mg/L,(5.06±1.04)g/L. Prothrombin time(PT), thrombin time(TT), and partial thromboplastin time(APTT)were(12.24±1.59)s,(18.33±3.56)s,(32.83±5.49)s,(9.86±1.83)s,(15.22±3.67)s, and(28.11±5.04)s which were longer than those in the control group(9.86±1.83)s、(15.22±3.67)s、(28.11±5.04)s, and the differences were statistically significant(P<0.05). Neither group occurred serious adverse reactions. Conclusions Low-dose aspirin can reduce the incidence of patients with high-risk pregnancy-induced hypertension, improve coagulation function indicators, and has fewer adverse reactions, which is safe and reliable.