孟鲁司特对哮喘患者外周血炎性反应因子IL-4、IFN-γ的作用和睡眠的影响

Effects of Montelukast on Inflammatory Cytokines IL-4 and IFN-γand Sleep in Patients with Asthma

目的:观察孟鲁司特对哮喘患者外周血炎性反应因子IL-4、IFN-γ的作用和睡眠的影响。方法:选取2018年6月至2019年6月山东省临沂市沂南县人民医院药剂科收治的哮喘患者88例作为研究对象,随机分为观察组和对照组,每组44例。对照组给予布地奈德治疗,观察组在对照组基础上加服孟鲁司特钠,2组患者共治疗14 d。比较2组治疗后咳嗽、睡眠、日间和夜间症状评分;记录并分析睡眠监测结果,检测炎性反应因子IL-4、IFN-γ水平。结果:治疗后2组IL-4、IFN-γ水平均降低,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后2组咳嗽、睡眠、日间及夜间症状评分较治疗前均下降,且观察组各评分指标均低于对照组,差异有统计学意义(P<0.05);治疗后2组睡眠评分均降低,且观察组优于对照组,差异有统计学意义(P<0.05)。结论:孟鲁司特能显著降低哮喘患者炎性反应因子水平,改善睡眠,有助于患者康复。

Objective:To observe the effects of Montelukast on inflammatory cytokines IL-4 and IFN-γand sleep in patients with asthma.Methods:A total of 88 patients with asthma were selected and randomly divided into observation group and control group,with 44 patients in each group.The control group was treated with budesonide,and the observation group was treated with montelulast sodium on the basis of the control group.Patients in the two groups were treated for a total of 14 days.Symptoms scores of cough,sleep,daytime and nighttime were compared between the two groups after treatment.Sleep monitoring results were recorded and analyzed to detect levels of inflammatory cytokines IL-4 and IFN-γ.Results:After treatment,the levels of IL-4 and IFN-were decreased,and the levels of the observation group were lower than those of the control group,with statistically significant difference between the two groups(P<0.05).The scores of cough,sleep,daytime and nighttime symptoms in the two groups decreased after treatment,and the scores in the observation group were lower than those in the control group.The sleep scores of both groups decreased after treatment,and the observation group was better than the control group.Conclusion:Montelukast can significantly reduce the level of inflammatory factors in asthma patients,improve sleep,and help patients recover.