中性粒细胞计数、中性粒细胞与淋巴细胞比值对突发性聋预后的影响

Effects of neutrophil count,neutrophil to lymphocyte ratio on the prognosis of sudden deafness

[目的]探讨中性粒细胞计数、中性粒细胞与淋巴细胞比值(NLR)对突发性聋预后的影响.[方法]回顾性分析自2014年1月至2017年11月间收治的369例突发性聋患者的临床资料,其中低频下降型82例,高频下降型37例,平坦下降型105例,全聋型145例;男性145例,女性224例;平均年龄(50.2±10.5)岁.按照突发性聋的诊断标准分型统计中性粒细胞计数,并计算NLR,分析其对突发性聋预后的影响.[结果]全聋型、平坦型、高频下降型突发性聋患者中性粒细胞计数>7.0×10^9/L组与≤7.0×10^9/L组痊愈率间差异无统计学意义(P>0.05),但总有效率间差异有统计学意义(P<0.05),低频下降型突发性聋患者中性粒细胞计数>7.0×10^9/L组与≤7.0×10^9/L组痊愈率及总有效率间差异均有统计学意义(P<0.05).预后为无效与有效、显效、治愈3种疗效患者NLR间差异均有统计学意义(P<0.0001);低频下降型与其他3种类型NLR间存在明显差异(P<0.01).[结论]突发性聋患者4种听力曲线类型中中性粒细胞计数与NLR均可反映预后,中性粒细胞计数与NLR高则预后好,支持炎症理论在突发性聋发病机制中的作用,其中低频下降型突发性聋患者中性粒细胞计数及NLR均较其他3种听力曲线类型高,提示中性粒细胞计数及NLR是评估突发性聋预后的可靠指标,在评估低频下降型突发性聋患者的预后时更为敏感.

OBJECTIVE To investigate the effects of neutrophil count,neutrophil to lymphocyte ratio(NLR)on the prognosis of sudden deafness.METHODS Clinical data of 369 patients with sudden deafness from January 2014 to November 2017 were retrospectively analyzed.There were 82 cases of low frequency decline,37 cases of high frequency decline,105 cases of flat decline and 145 cases of total deafness.There were 145 males and 224 females,the average age was 50.2±10.5.Neutrophils were counted according to the diagnostic criteria of sudden deafness and the NLR was calculated to analyze their influence on the prognosis of sudden deafness.RESULTS There was no statistically significant difference in the recovery rate of neutrophil count>7.0×10^9/L group and≤7.0×10^9/L group in the total deafness type,flat type and high frequency decline type of patients with sudden deafness(P>0.05),however,the difference of total effective rate was statistically significant(P<0.05).There were statistically significant differences in the recovery rate and total effective rate between neutrophil count>7.0×10^9/L group and≤7.0×10^9/L group in low frequency decline type of patients with sudden deafness(P<0.05).There were statistically significant differences in NLR between patients with the prognosis of the three types of efficacy:invalid and effective,significant and cured(P<0.0001).The NLR of low frequency decline type was significantly different from that of the other three types(P<0.01).CONCLUSION Neutrophil count and NLR in the 4 types of hearing curve of patients with sudden deafness can reflect the prognosis.A high neutrophil count and NLR have a good prognosis,supporting the role of inflammation in the pathogenesis of sudden deafness.Neutrophil count and NLR were higher in the patients with low frequency decline sudden deafness than the other three types of hearing curve,suggesting that neutrophil count and NLR are reliable indicators for evaluating the prognosis of sudden deafness,and they are more sensitive to evaluate the prognosis of patients with low frequency decline sudden deafness.