多发性皮肤非典型纤维黄色瘤1例

A Case of Multiple Cutaneous Atypical Fibroxanthoma

患者女,71岁,全身多发皮肤结节6年余。皮损组织病理示:瘤体内可见大量梭形细胞、组织细胞及巨细胞,呈杂乱性生长,梭形细胞和组织细胞具有显著多形性,可见较多异常核分裂象。部分多核巨细胞的胞核排列呈花圈状。免疫组织化学示:肿瘤细胞阳性表达CD10、CD68,部分表达Ki-67(15%),不表达CD34、平滑肌肌动蛋白(SMA)、平滑肌结蛋白(Desmin)、S-100。诊断:非典型纤维黄色瘤。

A 71-year-old female presented multiple cutaneous nodules for more than 6 years.The histopathology showed that there were a large number of spindle cells,histiocytes and giant cells in the tumor,which grew disorderly.Spindle cells and histiocytes had significant pleomorphism and abnormal mitoses.Nuclei of some multinucleated giant cells were arranged in a wreath.Immunohistochemical profile revealed CD10(+),CD68(+),Ki-67 index 15%,CD34(-),SMA(-),desmin(-)and S-100(-).The diagnosis of atypical fibroxanthoma was made.