IL-9在皮肤病发病机制中的研究进展

Research Progress of IL-9 in the Pathogenesis of Skin Diseases

白细胞介素9(IL-9)是由不同免疫细胞产生的多效功能细胞因子。其来源包括肥大细胞,自然杀伤T淋巴(NKT)细胞,Th2,Th17,Treg和ILC2细胞,而IL-9的主要生产者是Th9细胞。IL-9为多效性促炎因子,其在过敏、抗炎及肿瘤免疫调节过程中均起作用。近年来研究发现IL-9参与银屑病、系统性红斑狼疮、特应性皮炎及黑素瘤等疾病的病理过程。本文就IL-9的生物学作用及其与皮肤疾病的相关性进行综述。

Interleukin 9(IL-9)is a pleiotropic functional cytokine produced by different immune cells.Sources of IL-9 include mast cells,natural killer T lymphocytes(NKT),Th2,Th17,Treg and ILC2 cells,while the main producers of IL-9 are Th9 cells.IL-9 is a multi-acting pro-inflammatory factor that plays an important role in allergies,anti-inflammatory and tumor immune regulation.In recent years,studies have found that IL-9 is involved in the pathological processes of psoriasis,systemic lupus erythematosus,atopic dermatitis,and melanoma.In this report,we review recent advances in the biological effects of IL-9 and its correlation with skin diseases.