重复低频经颅磁刺激联合阿戈美拉汀治疗老年抑郁症的效果及其对血清NE、5-HT水平的影响

Effect of Repetitive Low-frequency Transcranial Magnetic Stimulation Combined with Agomelatine on Serum NE and 5-HT Levels in Elderly Patients with Depression

目的:探讨重复低频经颅磁刺激联合阿戈美拉汀治疗老年抑郁症患者的效果及其对血清去甲肾上腺素(NE)、5-羟色胺(5-HT)水平的影响。方法:选择2019年1-12月笔者所在医院收治的年龄≥60岁的老年抑郁症患者64例,使用抛掷硬币法将其分为对照组和试验组,每组32例。对照组使用阿戈美拉进行治疗,试验组使用重复低频经颅磁刺激联合阿戈美拉汀治疗,治疗后对比两组临床疗效、血清NE、5-HT水平、抑郁情况。结果:试验组总有效率(87.5%)高于对照组(65.62%),差异有统计学意义(P<0.05);治疗后试验组NE、5-HT水平均高于对照组,差异均有统计学意义(P<0.05);试验组治疗4、8周后汉密尔顿抑郁量表(HAMD)评分均低于对照组,差异均有统计学意义(P<0.05)。结论:重复低频经颅磁刺激联合阿戈美拉汀治疗老年抑郁症患者效果显著,能够提高患者NE、5-HT水平,改善抑郁情况。

Objective:To investigate the effect of repetitive low-frequency transcranial magnetic stimulation combined with Agomelatine on elderly patients with depression and its effect on serum norepinephrine(NE)and serotonin(5-HT)levels.Method:From January to December 2019,64 elderly patients with depression aged over 60 years were selected and divided into the control group and the experimental group by coin flipping method,32 cases in each group.The control group was treated with Agomelatine,and the experimental group was treated with repeated low-frequency transcranial magnetic stimulation combined with Agomelatine.After treatment,the clinical efficacy,serum NE,5-HT levels and depression of the two groups were compared.Result:The total effective rate in the experimental group(87.5%)was higher than that in the control group(65.62%),the difference was statistically significant(P<0.05).The levels of NE and 5-HT in the experimental group after treatment were higher than those in the control group,the differences were statistically significant(P<0.05).The Hamilton depression scale(HAMD)scores in the experimental group after four and eight weeks of treatment were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Repeated low-frequency transcranial magnetic stimulation combined with Agomelatine has a significant effect in the treatment of elderly patients with depression,which can improve the level of NE and 5-HT and improve the depression.