降钙素原联合超敏C反应蛋白检测在妊娠晚期B族链球菌感染中的意义

Significance of Procalcitonin Combined with Hypersensitive C-reactive Protein in the Detection of Group B Streptococcus Infection in the Third Trimester of Pregnancy

目的:分析探究血清降钙素原(PCT)联合超敏C反应蛋白(hs-CRP)水平检测在妊娠晚期B族链球菌(GBS)感染中的预测价值和临床意义。方法:收集2019年1-12月在本院分娩的妊娠晚期GBS阳性孕妇103例的临床资料设为GBS组,另选取妊娠晚期正常孕妇40例设为对照组。抽取各组孕妇外周静脉血,取上层清液,应用免疫色谱法、免疫比浊法分别检测PCT和hs-CRP水平,根据检查结果对GBS组研究对象进一步完成分组,主要分为GBS带菌组、GBS亚临床感染组与绒毛膜羊膜炎组。比较各组孕妇血清PCT、hs-CRP水平,分析PCT联合hs-CRP检测诊断效能。结果:GBS组孕妇PCT、hs-CRP水平均明显高于对照组,差异均有统计学意义(P<0.05)。GBS带菌组、GBS亚临床感染组、绒毛膜羊膜炎组患者PCT、hs-CRP水平比较,差异均有统计学意义(P<0.05)。绒毛膜羊膜炎组PCT、hs-CRP水平均高于GBS带菌组和GBS亚临床感染组,差异均有统计学意义(P<0.05)。PCT联合hs-CRP检测诊断GBS感染的阳性预测值、灵敏度、特异度均高于各单项检测方法。结论:妊娠晚期GBS感染孕妇血清PCT、hs-CRP水平均显著升高,联合检测PCT与hs-CRP对预测宫内感染有重要诊断价值和临床指导意义。

Objective:To analyze and explore the predictive value and clinical significance of serum procalcitonin (PCT) combined with hypersensitive C-reactive protein (hs-CRP) in the detection of group B streptococcus (GBS) infection in the third trimester of pregnancy.Method:The clinical data of 103 cases of GBS positive pregnant women in the third trimester of pregnancy delivered in our hospital from January to December 2019 were collected as GBS group,and 40 cases of normal pregnant women in late pregnancy were selected as the control group.The peripheral venous blood and supernatant of pregnant women in each group were collected,the levels of PCT and hs-CRP were detected by immunochromatography and immunoturbidimetric method respectively,according to the examination results,the subjects in GBS group were further divided into groups,they were divided into GBS carrier group,GBS subclinical infection group and catholicism group.The serum PCT andhs-CRP levels of pregnant women in each group were compared,and the diagnostic efficacy of PCT combined with hs-CRP was analyzed.Result:The levels of PCT and hs-CRP in GBS group were significantly higher than those in control group,the differences were statistically significant (P<0.05).Comparison of PCT and hs-CRP levels in GBS carrier group,GBS subclinical infection group,and catholicism group,the differences were statistically significant (P<0.05).The levels of PCT and hs-CRP in catholicism group were higher than those in GBS carrier group and GBS subclinical infection group,the differences were statistically significant (P<0.05).The positive predictive value,sensitivity and specificity of PCT combined with hs-CRP in the diagnosis of GBS infection were higher than those of single detection methods.Conclusion:The serum PCT and hs-CRP levels of pregnant women with GBS infection in the third trimester of pregnancy were significantly increased.The combined detection of PCT and hs-CRP has important diagnostic value and clinical significance in predicting intrauterine infection.