组蛋白变体macroH2A1调控肿瘤增殖的研究进展

Progress of histone variant macroH2A1 in tumor proliferation

组蛋白变体不仅为染色质提供独特的功能,而且通过特殊的沉积和清除机制参与基因表达调控。macroH2A1是主要的组蛋白变体之一,早期发现其与女性X染色体失活和转录抑制有关,但目前研究发现其在特定的条件下可通过调控细胞衰老和代谢抑制肿瘤增殖。该文基于目前研究进展阐述macroH2A1调控基因表达的分子机制及其在肿瘤进展中的作用。

Histone variants confer chromatin unique properties and also participate in the regulation of genetic expression through specific deposition and removal machineries.macroH2A1 is one of histone variants and has been found implicating in female X chromosome inactivation and transcriptional repression.However,recent marcoH2A1 has been reported to suppress tumor proliferation through regulating cellular senescence and metabolism under specific situations.The paper reviews the roles of macroH2A1 in tumorigenesis and the molecular mechanisms in regulating genetic expression based on current research progress.