多系统萎缩生物标志物的研究进展

Progress in biomarkers of multiple system atrophy

多系统萎缩是以自主神经、锥体外系、锥体束等多系统受累为特点的一种帕金森综合征,对左旋多巴反应不佳。该病临床诊断难度大,多数生物标志物特异度和敏感度均不高。因此,有研究建议将多项指标结合应用以提高诊断的准确度。除体液中的生物化学标志物外,影像学、病理学等生物标志物的相关研究也取得了一定进展。该文综述近年来多系统萎缩生物标志物的研究进展,包括血液和脑脊液中的蛋白和miRNA,以及影像学特征和外周组织中的α-突触核蛋白沉积。

Multiple system atrophy is a neurodegenerative disease,which is characterized by a combination of autonomic failure,Parkinsonian features,pyramidal and cerebellar dysfunction,and is poorly reactive to levodopa.Few biomarkers with high sensitivity or specificity have been applicable in the diagnosis of multiple system atrophy,making it a challenge to correctly diagnose this disease.Therefore,some researches combined several biomarkers to improve the diagnosis accuracy.Apart from those in body fluid,progress has been made in new biomarkers of neuroimaging and pathology.In this review,the advances in the identification of biomarkers of multiple system atrophy are summarized,and some candidate biomarkers that worth more investigation,including proteins and miRNAs in blood or cerebrospinal fluid,parameters in molecular and functional imaging,and pathologic features of peripheral tissue are described.