STZ制备糖尿病大鼠模型影响因素的研究进展

Research progress on factors influencing streptozotocin-induced diabetic rat models

糖尿病(diabetes mellitus,DM)已成为世界范围的流行病,发病率逐年增加。为了更深入探究DM的发病机制、研发更有效的预防、治疗方案,研究人员需要和人类疾病相似的、稳定、可复制的动物模型。使用链脲佐菌素(streptozotocin,STZ)诱导DM已半世纪之久,是目前基础研究中使用最广泛的DM动物诱导药物。本文对STZ制备DM大鼠模型过程中的主要影响因素进行简要综述,综合相关已发表文献的研究成果及经验,以期能对今后STZ诱导的DM大鼠模型的制备提出一些可参考的建议。

Diabetes mellitus(DM)has become a worldwide epidemic,with an increasing incidence year by year.To further explore the pathogenesis of DM and develop more effective prevention and treatment programs,researchers need stable,replicable animal models that are similar to human diseases.The administration of streptozotocin(STZ)has been used for half a century to induce DM,and is the most widely used method for establishing animal models of DM in basic research.In this paper,the main factors influencing STZ-induced DM rat models are briefly reviewed.On the basis of the research result and related literature,some suggestions for the future preparation of STZ-induced DM rat models are made.