原发性头痛动物模型的建立及评价方法的研究进展

Advances in the establishment and evaluation of animal models of primary headache

原发性头痛是高致残率的疾病之一,往往于青壮年时期发病,患者在承受痛苦的同时也给社会带来沉重的疾病负担,然而其发病机制尚不明确。切实可靠的原发性头痛动物模型的建立有助于探索原发性头痛的发病机制并研发预防治疗的药物,本文将从模型建立的原理方法评价、适用范围以及各模型的优缺点等方面对现有原发性头痛动物模型的建立及评价方法的研究进展进行综述。

Primary headache is a condition with a high disability rate,particular in young adults.It not only brings suffering to the patients but also places a heavy burden on society.However,the pathogenesis of primary headache is still unclear.The establishment of reliable animal models of primary headache is helpful to explore the pathogenesis and develop drugs for prevention and treatment.Here,we comprehensively summarize animal models of primary headache in recent years from the perspectives of animal model principles,methods evaluations,scope of application,and advantages and disadvantages.