中医辨证治疗对改善缓解期儿童哮喘肺功能的临床疗效分析

Clinical Effect Analysis of Syndrome Differentiation of Traditional Chinese Medicine on Improving Pulmonary Function of Asthma in Children in Remission

目的:研究中医辨证治疗对缓解期哮喘患儿肺功能的改善情况,从而为持续肺功能异常的哮喘缓解期患儿提供更好的治疗手段。方法:收集2019.1.1~2019.12.31在上海儿童医学中心呼吸哮喘门诊就诊的儿童哮喘缓解期患儿共88例,收集其相关临床资料,并根据其是否接受中医辨证治疗分为中医辨证治疗组和非中医辨证治疗组,比较其治疗3月后的相关肺功能参数。结果:两组在性别、年龄、病程时间及规范抗哮喘治疗时间之间对比无统计学差异(P>0.05)。两组患儿均按照儿童肺功能系列指南肺容积和通气功能部分的肺功能检查流程分别在其入组时及随访3月后进行常规肺通气功能检查,对其肺功能检查结果进行评价。治疗前,两组FEV1%(实测/预计)%、FEV1/VCmax%(实测/预计)%、FEF50%(实测/预计)%、MMEF%(实测/预计)%、FEF75%(实测/预计)%对比差异无统计学意义(P>0.05);治疗3个月后,中医辨证治疗组的上述指标均显著升高(P<0.05),非中医辨证治疗组的上述指标与治疗前差异无统计学意义(P>0.05),组间比较显示中医辨证治疗组的上述指标显著高于非中医辨证治疗组(P<0.05)。结论:中医辨证治疗能改善缓解期哮喘患儿的肺功能水平,中医辨证治疗辅以西医规范化抗哮喘治疗能获得更好的临床疗效。

Objective: Study on the improvement of lung function of children with asthma in remission during TCM syndrome differentiation treatment, so as to provide better treatment for children with asthma in remission with persistent pulmonary abnormalities.Methods: A total of 88 children with asthma in remission who were treated at the Shanghai Children’s Medical Center Respiratory Asthma Clinic from 2019.1.1 to 2019.12.31. In the TCM syndrome differentiation treatment group, the relevant pulmonary function parameters were compared after 3 months of treatment. Results: There was no significant difference between the two groups in terms of gender,age, duration of disease and standard anti-asthma treatment time(P>0.05). Children in both groups were subjected to routine pulmonary ventilation tests at the time of enrollment and 3 months follow-up according to the lung volume and ventilation function procedures of the Children’s Pulmonary Function Series Guidelines, and their lung function tests were evaluated. Before treatment, FEV1%(measured/expected)%, FEV1/VCmax%(measured/expected)%, FEF50%(measured/expected)%, MMEF%(measured/expected)%, FEF75%(measured/expected) % Contrast difference was not statistically significant(P>0.05). After 3 months of treatment, the above indexes of the TCM syndrome differentiation treatment group were significantly increased(P<0.05), and the non-TCM syndrome differentiation treatment group had no statistical difference from the pre-treatment difference Significance(P>0.05), the comparison between the groups showed that the above indicators of the TCM syndrome differentiation treatment group were significantly higher than those of the non-Chinese medicine syndrome treatment group(P<0.05). Conclusion: TCM syndrome differentiation treatment can improve the pulmonary function of children with asthma in remission. TCM syndrome differentiation treatment combined with western medicine standardized anti-asthma treatment can achieve better clinical efficacy.